A 987306

Discontinued Product

A 987306 (Cat. No. 3640) has been withdrawn from sale for commercial reasons.
Cat.No. 3640 - A 987306 | C18H25N5O | CAS No. 1082954-71-9
Description: Potent and selective H4 antagonist
Chemical Name: (±)-(7aR*,11aR*)-5,6,7a,8,9,10,11,11a-Octahydro-4-(1-piperazinyl)-benzofuran[2,3-h]quinazolin-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for A 987306

A 987306 is a potent histamine H4 receptor antagonist (pKi values are 8.24 and 8.47 in human and rat H4 receptors respectively). Displays 162-fold, 620-fold, and > 1600-fold selectivity over human H3, H1 and H2 receptors. Blocks zymosan-induced neutrophil reflux and attenuates thermal hypersensitivity in vivo (ED50 = 42 μmol/kg, ip).

Technical Data for A 987306

M. Wt 327.42
Formula C18H25N5O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1082954-71-9
PubChem ID 25109291
InChI Key DJKJVWJQAVGLHJ-YPMHNXCESA-N
Smiles NC3=NC1=C(C(N4CCNCC4)=N3)CCC2=C1[C@@](CCCC5)([H])[C@@]5([H])O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for A 987306

Certificate of Analysis / Product Datasheet
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References for A 987306

References are publications that support the biological activity of the product.

Liu et al (2008) cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. J.Med.Chem. 51 7094 PMID: 18983139

Leurs et al (2009) Molecular and biochemical pharmacology of the histamine H4 receptor. Br.J.Pharmacol. 157 14 PMID: 19413568

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Keywords: A 987306, A 987306 supplier, potent, selective, H4, histamine, histaminergic, receptors, antagonists, A987306, Histamine, Receptors, 3640, Tocris Bioscience

Citations for A 987306

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Currently there are no citations for A 987306.

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Literature in this Area

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