A 867744

Pricing Availability   Qty
Description: Positive allosteric modulator of α7 nAChRs
Chemical Name: 4-[5-(4-Chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]benzenesulfonamide
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for A 867744

A 867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs. Brain penetrant.

Technical Data for A 867744

M. Wt 402.89
Formula C20H19ClN2O3S
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 1000279-69-5
PubChem ID 23642319
InChI Key ABACVOXFUHDKNZ-UHFFFAOYSA-N
Smiles O=C(CC)C1=C(C)N(C3=CC=C(S(N)(=O)=O)C=C3)C(C2=CC=C(Cl)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 867744

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.29 100
ethanol 4.03 10 with gentle warming

Preparing Stock Solutions for A 867744

The following data is based on the product molecular weight 402.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.41 mL 24.82 mL
5 mM 0.5 mL 2.48 mL 4.96 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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View all Nicotinic (α7) Receptor Modulators

Keywords: A 867744, A 867744 supplier, A867744, positive, allosteric, modulators, a7, alpha7, acetylcholine, nicotinic, receptors, nAChRs, selective, PAM, Nicotinic, (a7), Receptors, 4571, Tocris Bioscience

Citations for A 867744

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

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Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.