A 844606

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Cat.No. 4477 - A 844606 | C20H20N2O2 | CAS No. 861119-08-6
Description: Selective α7 nAChR partial agonist
Chemical Name: 2-(Hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 values are 1.4 and 2.2 μM at human and rat receptors respectively). Displays no measurable effect on α4β2 nAChRs. Stimulates α7 nAChR-induced ERK1/2 phosphorylation in PC12 cells.

Technical Data

M. Wt 320.38
Formula C20H20N2O2
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 861119-08-6
PubChem ID 11461365
InChI Key WUJHMDPPANTBTQ-UHFFFAOYSA-N
Smiles O=C2C3=C(C=CC(N4CC(CN(C)C5)C5C4)=C3)OC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 1.6 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 320.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 62.43 mL 312.13 mL 624.26 mL
0.25 mM 12.49 mL 62.43 mL 124.85 mL
0.5 mM 6.24 mL 31.21 mL 62.43 mL
2.5 mM 1.25 mL 6.24 mL 12.49 mL

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References

References are publications that support the biological activity of the product.

Briggs et al (2008) Alpha7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues. Br.J.Pharmacol. 153 1054 PMID: 18157163


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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