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Selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.
(Modifications: Ala-7 = D-Ala)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Bruce et al (2015) Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br.J.Pharmacol. 172 2219 PMID: 25522140
Becker et al (2005) Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats. Brain Res. 1040 121 PMID: 15804433
Santos et al (1994) Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res.Bull. 35 293 PMID: 7850477
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Keywords: A 779, A 779 supplier, A779, selective, mas, receptors, antagonists, angiotensin, ang-(1-7), Other, Angiotensin, Receptors, 5937, Tocris Bioscience
2 Citations for A 779
Citations are publications that use Tocris products. Selected citations for A 779 include:
Dominska et al (2018) Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer. Sci.Rep. 8 15772 PMID: 30361641
Moreno-Santos et al (2020) Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats. Behav.Brain Res. PMID: 33011187
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