A 779

Pricing Availability Delivery Time Qty
Cat.No. 5937 - A 779 | Asp-Arg-Val-Tyr-Ile-His-D-Ala | CAS No. 159432-28-7
Description: Selective Mas receptor (Ang-(1-7) receptor) antagonist

Biological Activity

Selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.

Technical Data

M. Wt 872.98
Formula C39H60N12O11
Sequence DRVYIHA

(Modifications: Ala-7 = D-Ala)

Storage Store at -20°C
CAS Number 159432-28-7
PubChem ID 10169886
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 872.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.73 mL 11.46 mL
5 mM 0.23 mL 1.15 mL 2.29 mL
10 mM 0.11 mL 0.57 mL 1.15 mL
50 mM 0.02 mL 0.11 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet


References are publications that support the products' biological activity.

Bruce et al (2015) Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br.J.Pharmacol. 172 2219 PMID: 25522140

Becker et al (2005) Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats. Brain Res. 1040 121 PMID: 15804433

Santos et al (1994) Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res.Bull. 35 293 PMID: 7850477

If you know of a relevant reference for A 779, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Angiotensin Receptor Antagonists

Keywords: A 779, supplier, A779, selective, mas, receptors, antagonists, angiotensin, ang-(1-7), Other, Angiotensin, Receptors, Other, Angiotensin, Receptors, Tocris Bioscience

Citations for A 779

Citations are publications that use Tocris products.

Currently there are no citations for A 779. Do you know of a great paper that uses A 779 from Tocris? If so please let us know.

Reviews for A 779

There are currently no reviews for this product. Be the first to review A 779 and earn rewards!

Have you used A 779?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Aptamers
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells