A 779

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Cat.No. 5937 - A 779 | Asp-Arg-Val-Tyr-Ile-His-D-Ala | CAS No. 159432-28-7
Description: Selective Mas receptor (Ang-(1-7) receptor) antagonist

Biological Activity

Selective Mas receptor (Ang-(1-7) receptor) antagonist. Exhibits no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. Inhibits antidiuretic effect of Ang-(1-7) in water-loaded rats. Also attenuates Monocrotaline-induced pulmonary fibrosis in rats.

Technical Data

M. Wt 872.98
Formula C39H60N12O11
Sequence DRVYIHA

(Modifications: Ala-7 = D-Ala)

Storage Store at -20°C
CAS Number 159432-28-7
PubChem ID 10169886
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 872.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.73 mL 11.46 mL
5 mM 0.23 mL 1.15 mL 2.29 mL
10 mM 0.11 mL 0.57 mL 1.15 mL
50 mM 0.02 mL 0.11 mL 0.23 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Bruce et al (2015) Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis. Br.J.Pharmacol. 172 2219 PMID: 25522140

Becker et al (2005) Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats. Brain Res. 1040 121 PMID: 15804433

Santos et al (1994) Characterization of a new angiotensin antagonist selective for angiotensin-(1-7): evidence that the actions of angiotensin-(1-7) are mediated by specific angiotensin receptors. Brain Res.Bull. 35 293 PMID: 7850477

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Keywords: A 779, supplier, A779, selective, mas, receptors, antagonists, angiotensin, ang-(1-7), Other, Angiotensin, Receptors, Other, Angiotensin, Receptors, Tocris Bioscience

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