A-7 hydrochloride

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Cat.No. 0378 - A-7 hydrochloride | C20H29ClN2O2S.HCl | CAS No. 79127-24-5
Description: Calmodulin antagonist
Chemical Name: N-(10-Aminodecyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
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Biological Activity

Potent calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC50 of 3 μM).

Technical Data

M. Wt 433.44
Formula C20H29ClN2O2S.HCl
Storage Store at RT
CAS Number 79127-24-5
PubChem ID 2735312
InChI Key XDJCAQBTSCRBHS-UHFFFAOYSA-N
Smiles Cl.NCCCCCCCCCCNS(=O)(=O)C1=C2C=CC=C(Cl)C2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.67 50

Preparing Stock Solutions

The following data is based on the product molecular weight 433.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.61 mL 23.07 mL 46.14 mL
2.5 mM 0.92 mL 4.61 mL 9.23 mL
5 mM 0.46 mL 2.31 mL 4.61 mL
25 mM 0.09 mL 0.46 mL 0.92 mL

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References

References are publications that support the biological activity of the product.

Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736

Itoh and Hidaka (1984) Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J.Biochem. 96 1721 PMID: 6099352


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