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Potent calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC50 of 3 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 433.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.61 mL||23.07 mL||46.14 mL|
|2.5 mM||0.92 mL||4.61 mL||9.23 mL|
|5 mM||0.46 mL||2.31 mL||4.61 mL|
|25 mM||0.09 mL||0.46 mL||0.92 mL|
References are publications that support the biological activity of the product.
Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736
Itoh and Hidaka (1984) Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J.Biochem. 96 1721 PMID: 6099352
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Keywords: A-7 hydrochloride, A-7 hydrochloride supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Ca2+-calmodulin-dependent, phosphodiesterase, 0378, Tocris Bioscience
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