A 582941

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Cat.No. 4341 - A 582941 | C17H20N4 | CAS No. 848591-90-2
Description: Partial agonist at α7 nAChR
Chemical Name: Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective α7 nAChR partial agonist; exhibits high affinity for both rat and human α7 receptors (Ki values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for α7 over 5-HT3 receptors (Ki = 150 nM for 5-HT3).

Compound Libraries

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Technical Data

M. Wt 280.37
Formula C17H20N4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 848591-90-2
PubChem ID 44190553
InChI Key GTMRUYCIJSNXGB-GASCZTMLSA-N
Smiles [H][C@@]12[C@@](CN(C3=CC=C(C4=CC=CC=C4)N=N3)C2)([H])CN(C)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.04 100
1eq. HCl 14.02 50

Preparing Stock Solutions

The following data is based on the product molecular weight 280.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.57 mL 17.83 mL 35.67 mL
5 mM 0.71 mL 3.57 mL 7.13 mL
10 mM 0.36 mL 1.78 mL 3.57 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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References

References are publications that support the biological activity of the product.

Anderson et al (2008) [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain J.Pharmacol.Exp.Ther. 324 179 PMID: 17959745


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Keywords: A 582941, A 582941 supplier, A582941, selective, alpha7, α7, a7, nicotinics, receptors, partial, agonists, Nicotinic, (a7), Receptors, 4341, Tocris Bioscience

Citations for A 582941

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Literature in this Area

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