A 582941

Pricing Availability   Qty
Description: α7 nAChR partial agonist
Chemical Name: Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for A 582941

A 582941 is a selective α7 nAChR partial agonist; exhibits high affinity for both rat and human α7 receptors (Ki values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for α7 over 5-HT3 receptors (Ki = 150 nM for 5-HT3).

Technical Data for A 582941

M. Wt 280.37
Formula C17H20N4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 848591-90-2
PubChem ID 44190553
InChI Key GTMRUYCIJSNXGB-GASCZTMLSA-N
Smiles [H][C@@]12[C@@](CN(C3=CC=C(C4=CC=CC=C4)N=N3)C2)([H])CN(C)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 582941

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.04 100
1eq. HCl 14.02 50

Preparing Stock Solutions for A 582941

The following data is based on the product molecular weight 280.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.57 mL 17.83 mL 35.67 mL
5 mM 0.71 mL 3.57 mL 7.13 mL
10 mM 0.36 mL 1.78 mL 3.57 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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References for A 582941

References are publications that support the biological activity of the product.

Anderson et al (2008) [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain J.Pharmacol.Exp.Ther. 324 179 PMID: 17959745


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Keywords: A 582941, A 582941 supplier, A582941, selective, alpha7, α7, a7, nicotinics, receptors, partial, agonists, Nicotinic, (a7), Receptors, 4341, Tocris Bioscience

Citations for A 582941

Citations are publications that use Tocris products.

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Reviews for A 582941

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.