A-5 hydrochloride

Discontinued Product

Unfortunately A-5 hydrochloride (Cat. No. 0377) has been withdrawn from sale for commercial reasons.
Cat.No. 0377 - A-5 hydrochloride | CAS No. 78957-84-3
Description: Calmodulin antagonist
Chemical Name: N-(4-Aminobutyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

Biological Activity

Calmodulin antagonist (inhibits calmodulin-activated PDE activity with an IC50 of 66 μM).

Technical Data

M. Wt 349.27
Storage Store at RT
CAS Number 78957-84-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 349.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.32 mL 28.63 mL
5 mM 0.57 mL 2.86 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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Safety Datasheet


References are publications that support the products' biological activity.

Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588

Itoh and Hidaka (1984) Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J.Biochem. 96 1721 PMID: 6099352

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