A-3 hydrochloride

Discontinued Product

Unfortunately A-3 hydrochloride (Cat. No. 0366) has been withdrawn from sale for commercial reasons.
Cat.No. 0366 - A-3 hydrochloride | C12H13ClN2O2S.HCl
Description: Protein kinase inhibitor
Chemical Name: N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Datasheet
Citations
Literature

Biological Activity

Protein kinase inhibitor. Ki values are 4.3, 3.8, 7, 47, 80 and 5.1 μM for PKA, PKG, MLCK, PKC, casein kinase I and casein kinase II respectively.

Technical Data

M. Wt 321.22
Formula C12H13ClN2O2S.HCl
Storage Store at RT
Smiles Cl.NCCNS(=O)(=O)c1c2cccc(Cl)c2ccc1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 321.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.57 mL 31.13 mL
5 mM 0.62 mL 3.11 mL 6.23 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377 PMID: 1605572

Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736

Hidaka and Hagiwara (1987) Pharmacology of the isoquinolinesulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci. 8 162 PMID:

View Related Products by Target

View Related Products by Product Action

View all Broad Spectrum Protein Kinase Inhibitor Inhibitors

Keywords: A-3 hydrochloride, supplier, N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide, hydrochloride, Broad, Spectrum, Protein, Kinase, Inhibitors, Tocris Bioscience

Citations for A-3 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for A-3 hydrochloride.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for A-3 hydrochloride

Protocols

TODO: Add Protocols