Discontinued ProductUnfortunately A-3 hydrochloride (Cat. No. 0366) has been withdrawn from sale for commercial reasons.
Protein kinase inhibitor. Ki values are 4.3, 3.8, 7, 47, 80 and 5.1 μM for PKA, PKG, MLCK, PKC, casein kinase I and casein kinase II respectively.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 321.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.11 mL||15.57 mL||31.13 mL|
|5 mM||0.62 mL||3.11 mL||6.23 mL|
|10 mM||0.31 mL||1.56 mL||3.11 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References are publications that support the products' biological activity.
Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377 PMID: 1605572
Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736
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Keywords: A-3 hydrochloride, supplier, N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide, hydrochloride, Broad, Spectrum, Protein, Kinase, Inhibitors, Broad, Spectrum, Protein, Kinase, Inhibitors, Tocris Bioscience
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