A-3 hydrochloride

Discontinued Product

Unfortunately A-3 hydrochloride (Cat. No. 0366) has been withdrawn from sale for commercial reasons.
Cat.No. 0366 - A-3 hydrochloride | C12H13ClN2O2S.HCl
Description: Protein kinase inhibitor
Chemical Name: N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

Biological Activity

Protein kinase inhibitor. Ki values are 4.3, 3.8, 7, 47, 80 and 5.1 μM for PKA, PKG, MLCK, PKC, casein kinase I and casein kinase II respectively.

Technical Data

M. Wt 321.22
Formula C12H13ClN2O2S.HCl
Storage Store at RT
Smiles Cl.NCCNS(=O)(=O)c1c2cccc(Cl)c2ccc1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 321.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.57 mL 31.13 mL
5 mM 0.62 mL 3.11 mL 6.23 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377 PMID: 1605572

Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736

Hidaka and Hagiwara (1987) Pharmacology of the isoquinolinesulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci. 8 162 PMID:

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