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Discontinued Product
A-3 hydrochloride (Cat. No. 0366) has been withdrawn from sale for commercial reasons.
Description: Protein kinase inhibitor
Chemical Name: N-(2-Aminoethyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Biological Activity for A-3 hydrochloride
Protein kinase inhibitor. Ki values are 4.3, 3.8, 7, 47, 80 and 5.1 μM for PKA, PKG, MLCK, PKC, casein kinase I and casein kinase II respectively.
Technical Data for A-3 hydrochloride
| M. Wt | 321.22 |
| Formula | C12H13ClN2O2S.HCl |
| Storage | Store at RT |
| Smiles | Cl.NCCNS(=O)(=O)c1c2cccc(Cl)c2ccc1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for A-3 hydrochloride
References for A-3 hydrochloride
References are publications that support the biological activity of the product.
Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377 PMID: 1605572
Hidaka and Tanaka (1983) Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102 185 PMID: 6139736
Hidaka and Hagiwara (1987) Pharmacology of the isoquinolinesulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci. 8 162
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