Pricing Availability Delivery Time Qty
Cat.No. 5460 - 968 | C27H27BrN2O | CAS No. 311795-38-7
Description: Allosteric inhibitor of glutaminase
Chemical Name: 5-[3-Bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethylbenzo[a]phenanthridin-4(1H)-one
Purity: ≥99% (HPLC)

Biological Activity

Allosteric inhibitor of glutaminase. Blocks Rho-GTPase-dependent transformation of fibroblasts. Suppresses breast cancer cell growth and invasive activity in vitro. Also inhibits P-493 B lymphoma cell growth and reduces tumor size of P-493 cell xenografts in mice.

Technical Data

M. Wt 475.42
Formula C27H27BrN2O
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 311795-38-7
PubChem ID 3099980
Smiles BrC1=CC(C(C5=C4CC(C)(C)CC5=O)NC3=C4C2=CC=CC=C2C=C3)=CC=C1N(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.51 20

Preparing Stock Solutions

The following data is based on the product molecular weight 475.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.1 mL 10.52 mL 21.03 mL
5 mM 0.42 mL 2.1 mL 4.21 mL
10 mM 0.21 mL 1.05 mL 2.1 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Wang et al (2010) Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell 18 207 PMID: 20832749

Stalnecker et al (2015) Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 112 394 PMID: 25548170

Lu et al (2010) Cancer metabolism: is glutamine sweeter than glucose? Cancer Cell 18 199 PMID: 20832746

If you know of a relevant reference for 968, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Glutaminase Inhibitors

Keywords: 968, supplier, Hydrolases, allosteric, inhibitors, inhibits, glutaminase, oncogene, transformation, gls1, Glutaminase, Glutaminase, Tocris Bioscience

Citations for 968

Citations are publications that use Tocris products.

Currently there are no citations for 968. Do you know of a great paper that uses 968 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cancer Metabolism

Cancer Metabolism Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the main targets for cancer metabolism researchers. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways. These distinct metabolic circuits could provide viable cancer therapeutic targets.

Pathways for 968


TODO: Add Protocols