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Biological Activity for 9-AC
9-AC is a Cl- transport inhibitor with a moderate to strong inhibitory action on PKA activated cardiac IcI.
Technical Data for 9-AC
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 9-AC
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 9-AC
The following data is based on the product molecular weight 222.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.5 mL||22.5 mL||45 mL|
|5 mM||0.9 mL||4.5 mL||9 mL|
|10 mM||0.45 mL||2.25 mL||4.5 mL|
|50 mM||0.09 mL||0.45 mL||0.9 mL|
References for 9-AC
References are publications that support the biological activity of the product.
Cabantchik and Greger (1992) Chemical probes for anion transporters of mammalian cell membranes. Am.J.Physiol. 262 C803-C827 PMID: 1566811
Gadsby et al (1995) The CFTR chloride channel of mammalian heart. Annu.Rev.Physiol. 57 387 PMID: 7539989
Pusch et al (2006) Channel or transporter? The CLC saga continues. Exp.Physiol. 91 149 PMID: 16179405
Estévez et al (2003) Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron 38 47 PMID: 12691663
If you know of a relevant reference for 9-AC, please let us know.
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Keywords: 9-AC, 9-AC supplier, Chloride, transport, inhibitors, inhibits, Cl-, Channels, CFTR, Other, 0963, Tocris Bioscience
2 Citations for 9-AC
Citations are publications that use Tocris products. Selected citations for 9-AC include:
Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388 PMID: 15616319
Freeman et al (2013) Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. Online J Biol Sci 110 103 PMID: 23576702
Do you know of a great paper that uses 9-AC from Tocris? Please let us know.
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