9-AC

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Cat.No. 0963 - 9-AC | C15H10O2 | CAS No. 723-62-6
Description: Chloride transport inhibitor
Chemical Name: 9-Anthracenecarboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Cl- transport inhibitor with a moderate to strong inhibitory action on PKA activated cardiac IcI.

Technical Data

M. Wt 222.24
Formula C15H10O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 723-62-6
PubChem ID 2201
InChI Key XGWFJBFNAQHLEF-UHFFFAOYSA-N
Smiles OC(=O)C1=C2C=CC=CC2=CC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 10 mM in ethanol and to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 222.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.5 mL 22.5 mL 45 mL
5 mM 0.9 mL 4.5 mL 9 mL
10 mM 0.45 mL 2.25 mL 4.5 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cabantchik and Greger (1992) Chemical probes for anion transporters of mammalian cell membranes. Am.J.Physiol. 262 C803-C827 PMID: 1566811

Gadsby et al (1995) The CFTR chloride channel of mammalian heart. Annu.Rev.Physiol. 57 387 PMID: 7539989

Pusch et al (2006) Channel or transporter? The CLC saga continues. Exp.Physiol. 91 149 PMID: 16179405

Estévez et al (2003) Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron 38 47 PMID: 12691663


If you know of a relevant reference for 9-AC, please let us know.

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Keywords: Chloride transport inhibitors inhibits Cl- Channels CFTR Other Chloride Channels

2 Citations for 9-AC

Citations are publications that use Tocris products. Selected citations for 9-AC include:

Freeman et al (2013) Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. Online J Biol Sci 110 103 PMID: 23576702

Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388 PMID: 15616319


Do you know of a great paper that uses 9-AC from Tocris? If so please let us know.

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
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  • Transporters
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  • Stem Cells

Pathways for 9-AC

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