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9-AC is a Cl- transport inhibitor with a moderate to strong inhibitory action on PKA activated cardiac IcI.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Cabantchik and Greger (1992) Chemical probes for anion transporters of mammalian cell membranes. Am.J.Physiol. 262 C803-C827 PMID: 1566811
Gadsby et al (1995) The CFTR chloride channel of mammalian heart. Annu.Rev.Physiol. 57 387 PMID: 7539989
Pusch et al (2006) Channel or transporter? The CLC saga continues. Exp.Physiol. 91 149 PMID: 16179405
Estévez et al (2003) Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron 38 47 PMID: 12691663
Keywords: 9-AC, 9-AC supplier, Chloride, transport, inhibitors, inhibits, Cl-, Channels, CFTR, Other, 0963, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for 9-AC include:
Freeman et al (2013) Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. Online J Biol Sci 110 103 PMID: 23576702
Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388 PMID: 15616319
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