Cl- transport inhibitor with a moderate to strong inhibitory action on PKA activated cardiac IcI.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 10 mM in ethanol and to 100 mM in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 222.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.5 mL||22.5 mL||45 mL|
|5 mM||0.9 mL||4.5 mL||9 mL|
|10 mM||0.45 mL||2.25 mL||4.5 mL|
|50 mM||0.09 mL||0.45 mL||0.9 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Cabantchik and Greger (1992) Chemical probes for anion transporters of mammalian cell membranes. Am.J.Physiol. 262 C803-C827 PMID: 1566811
Gadsby et al (1995) The CFTR chloride channel of mammalian heart. Annu.Rev.Physiol. 57 387 PMID: 7539989
Pusch et al (2006) Channel or transporter? The CLC saga continues. Exp.Physiol. 91 149 PMID: 16179405
Estévez et al (2003) Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron 38 47 PMID: 12691663
If you know of a relevant reference for 9-AC, please let us know.
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Keywords: Chloride transport inhibitors inhibits Cl- Channels CFTR Other Chloride Channels
2 Citations for 9-AC
Citations are publications that use Tocris products. Selected citations for 9-AC include:
Freeman et al (2013) Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors. Online J Biol Sci 110 103 PMID: 23576702
Li et al (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother 49 388 PMID: 15616319
Do you know of a great paper that uses 9-AC from Tocris? If so please let us know.
Literature in this Area
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