666-15

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Cat.No. 5661 - 666-15 | C33H30ClN3O5.HCl | CAS No. 1433286-70-4
Description: Potent and selective CREB inhibitor
Chemical Name: 3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective CREB inhibitor (IC50 = 81 nM). Inhibits cancer cell growth, without harming normal cells (up to 1 μM). Completely suppresses tumor growth in a breast cancer xenograft model.

Technical Data

M. Wt 620.52
Formula C33H30ClN3O5.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1433286-70-4
PubChem ID 71566396
InChI Key LELLCPHHYHLWBH-UHFFFAOYSA-N
Smiles NCCCOC1=CC2=CC=CC=C2C=C1C(NCCOC3=C(C(NC4=CC=C(Cl)C=C4O)=O)C=C(C=CC=C5)C5=C3)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 62.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 620.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.61 mL 8.06 mL 16.12 mL
5 mM 0.32 mL 1.61 mL 3.22 mL
10 mM 0.16 mL 0.81 mL 1.61 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Xie et al (2015) Identification of a potent inhibitor of CREB-mediated gene transcription with efficacious in vivo anticancer activity J.Med.Chem. 58 5075 PMID: 26023867

Li et al (2016) Systemic inhibition of CREB is well-tolerated in vivo. Sci.Rep. 6 34513 PMID: 27694829


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Keywords: cyclic adenosine monophosphate cAMP response element binding protein CREB inhibitors inhibits breast cancer potent selective Other Transcription Factors

1 Citation for 666-15

Citations are publications that use Tocris products. Selected citations for 666-15 include:

Phua (2017) Angiopoietin-like 4 mediates colonic inflammation by regulating chemokine transcript stability via tristetraprolin. Sci Rep 7 44351 PMID: 28287161


Do you know of a great paper that uses 666-15 from Tocris? If so please let us know.

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