Discontinued Product

6'-Iodoresiniferatoxin (Cat. No. 1556) has been withdrawn from sale for commercial reasons.
Description: High affinity TRPV1 agonist/partial agonist
Alternative Names: 6'-IRTX
Chemical Name: [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]-4-hydroxy-2-iodo-5-methoxy-benzeneacetic acid methyl ester
Purity: ≥98% (HPLC)

Biological Activity for 6'-Iodoresiniferatoxin

High affinity TRPV1 (VR1) vanilloid receptor partial agonist (Ki = 0.71 nM; EC50 = 130 nM at human VR1). Displays partial agonism at human VR1 and full agonism at rat VR1.

Technical Data for 6'-Iodoresiniferatoxin

M. Wt 754.6
Formula C37H39IO9
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 335151-55-8
PubChem ID 10305903
Smiles O=C1C(C)=C[C@]2([H])[C@@](O)1CC(COC(CC5=C(I)C=C(O)C(OC)=C5)=O)=C[C@]3([H])[C@@](O6)2[C@H](C)C[C@@]4(C(C)=C)[C@@H]3OC6(CC7=CC=CC=C7)O4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for 6'-Iodoresiniferatoxin

References for 6'-Iodoresiniferatoxin

References are publications that support the biological activity of the product.

McDonnell et al (2002) Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor. Bioorg.Med.Chem.Lett. 12 1189 PMID: 11934585

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Keywords: 6'-Iodoresiniferatoxin, 6'-Iodoresiniferatoxin supplier, High, affinity, TRPV1, agonists, partial, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, 6-Iodoresiniferatoxin, 6-IRTX, 6'-IRTX, 1556, Tocris Bioscience

Citations for 6'-Iodoresiniferatoxin

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Currently there are no citations for 6'-Iodoresiniferatoxin.

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