6'-Iodoresiniferatoxin

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Cat.No. 1556 - 6'-Iodoresiniferatoxin | C37H39IO9 | CAS No. 335151-55-8
Description: High affinity TRPV1 agonist/partial agonist
Alternative Names: 6'-IRTX
Chemical Name: [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]-4-hydroxy-2-iodo-5-methoxy-benzeneacetic acid methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity TRPV1 (VR1) vanilloid receptor partial agonist (Ki = 0.71 nM; EC50 = 130 nM at human VR1). Displays partial agonism at human VR1 and full agonism at rat VR1.

Technical Data

M. Wt 754.6
Formula C37H39IO9
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 335151-55-8
PubChem ID 10305903
InChI Key IITCVPTZKLXSKQ-ZSVIJTOTSA-N
Smiles O=C1C(C)=C[C@]2([H])[C@@](O)1CC(COC(CC5=C(I)C=C(O)C(OC)=C5)=O)=C[C@]3([H])[C@@](O6)2[C@H](C)C[C@@]4(C(C)=C)[C@@H]3OC6(CC7=CC=CC=C7)O4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol and in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 754.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.33 mL 6.63 mL 13.25 mL
5 mM 0.27 mL 1.33 mL 2.65 mL
10 mM 0.13 mL 0.66 mL 1.33 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

McDonnell et al (2002) Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor. Bioorg.Med.Chem.Lett. 12 1189 PMID: 11934585


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Citations for 6'-Iodoresiniferatoxin

Citations are publications that use Tocris products.

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Literature in this Area

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Pain Research Product Guide

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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.

Pathways for 6'-Iodoresiniferatoxin

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