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High affinity TRPV1 (VR1) vanilloid receptor partial agonist (Ki = 0.71 nM; EC50 = 130 nM at human VR1). Displays partial agonism at human VR1 and full agonism at rat VR1.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
McDonnell et al (2002) Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor. Bioorg.Med.Chem.Lett. 12 1189 PMID: 11934585
Keywords: 6'-Iodoresiniferatoxin, 6'-Iodoresiniferatoxin supplier, High, affinity, TRPV1, agonists, partial, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, 6-Iodoresiniferatoxin, 6-IRTX, 6'-IRTX, 1556, Tocris Bioscience
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.