6-Hydroxydopamine hydrobromide

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Cat.No. 2547 - 6-Hydroxydopamine hydrobromide | C8H11NO3.HBr | CAS No. 636-00-0
Description: Selective catecholaminergic neurotoxin
Alternative Names: 6-OHDA
Chemical Name: 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide
Citations (6)

Biological Activity

Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.

Technical Data

M. Wt 250.09
Formula C8H11NO3.HBr
Storage Desiccate at -20°C
CAS Number 636-00-0
PubChem ID 176170
Smiles NCCC1=CC(O)=C(O)C=C1O.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 20.56 100
water 20.56 100

Preparing Stock Solutions

The following data is based on the product molecular weight 250.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4 mL 19.99 mL 39.99 mL
5 mM 0.8 mL 4 mL 8 mL
10 mM 0.4 mL 2 mL 4 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Breese and Traylor (1970) Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: evidence for selective degeneration of catecholamine neurons. J.Pharmacol.Exp.Ther. 174 413 PMID: 5456173

Soto-Otero et al (2000) Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J.Neurochem. 74 1605 PMID: 10737618

Fujita et al (2006) Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 1113 10 PMID: 16945353

If you know of a relevant reference for 6-Hydroxydopamine hydrobromide, please let us know.

Keywords: 6-Hydroxydopamine hydrobromide, supplier, Selective, catecholaminergic, neurotoxin, Dopamine, Receptors, adrenoceptors, adrenergic, dopaminergic, neurotoxins, parkinson's, parkinsons, 6-OHDA, Dopaminergic-Related, Adrenergic, Related, Compounds, Dopaminergic-Related, Tocris Bioscience

6 Citations for 6-Hydroxydopamine hydrobromide

Citations are publications that use Tocris products. Selected citations for 6-Hydroxydopamine hydrobromide include:

Sérriàre et al (2015) Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model. PLoS One 2 61 PMID: 26389120

Reinhardt et al (2013) Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. Neural Plast 8 e59252 PMID: 23533608

Grau and Greene (2012) Use of PC12 cells and rat superior cervical ganglion sympathetic neurons as models for neuroprotective assays relevant to Parkinson's disease. Methods Mol Biol 846 201 PMID: 22367813

Malagelada et al (2010) Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J Neurosci 30 1166 PMID: 20089925

Malagelada et al (2008) RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation. J Neurosci 28 14363 PMID: 19118169

Fouillet et al (2012) ER stress inhibits neuronal death by promoting autophagy. Front Med (Lausanne) 8 915 PMID: 22660271

Do you know of a great paper that uses 6-Hydroxydopamine hydrobromide from Tocris? If so please let us know.

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