5J 4

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Description: CRAC channel blocker; anti-inflammatory
Chemical Name: N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity for 5J 4

5J 4 is a calcium release-activated calcium (CRAC) channel blocker. Blocks store-operated calcium entry (SOCE) in HeLa-O+S cells and Th17 cells in vitro. Ameliorates symptoms and reduces CNS infiltration by mononuclear cells in a mouse model of experimental autoimmune encephalomyelitis (EAE) in vivo.

Technical Data for 5J 4

M. Wt 312.34
Formula C16H12N2O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 827001-82-1
PubChem ID 2968289
Smiles OC1=CC2=C(C=C1)C(NC(NC(C3=CC=CO3)=O)=S)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 5J 4

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.23 100
ethanol 3.12 10

Preparing Stock Solutions for 5J 4

The following data is based on the product molecular weight 312.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 16.01 mL 32.02 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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References for 5J 4

References are publications that support the biological activity of the product.

Kim et al (2014) Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J.Immunol. 192 110 PMID: 24307733

If you know of a relevant reference for 5J 4, please let us know.

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Keywords: 5J 4, 5J 4 supplier, 5J4, CRAC, calcium, release, activated, store, operated, entry, SOCE, anti-inflammatory, channels, Ca2+, blockers, Other, Calcium, Channels, STIM-Orai, 5490, Tocris Bioscience

1 Citation for 5J 4

Citations are publications that use Tocris products. Selected citations for 5J 4 include:

Rao et al (2016) Homer1a attenuates glutamate-induced oxidative injury in HT-22 cells through regulation of store-operated calcium entry. Sci Rep 6 33975 PMID: 27681296

Do you know of a great paper that uses 5J 4 from Tocris? Please let us know.

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