5J 4

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Cat.No. 5490 - 5J 4 | C16H12N2O3S | CAS No. 827001-82-1
Description: CRAC channel blocker; anti-inflammatory
Chemical Name: N-[[(6-Hydroxy-1-naphthalenyl)amino]thioxomethyl]-2-furancarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity

Calcium release-activated calcium (CRAC) channel blocker. Blocks store-operated calcium entry (SOCE) in HeLa-O+S cells and Th17 cells in vitro. Ameliorates symptoms and reduces CNS infiltration by mononuclear cells in a mouse model of experimental autoimmune encephalomyelitis (EAE) in vivo.

Technical Data

M. Wt 312.34
Formula C16H12N2O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 827001-82-1
PubChem ID 2968289
InChI Key WMUSJLJASFXGHN-UHFFFAOYSA-N
Smiles OC1=CC2=C(C=C1)C(NC(NC(C3=CC=CO3)=O)=S)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 3.12 10
DMSO 31.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 312.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.2 mL 16.01 mL 32.02 mL
5 mM 0.64 mL 3.2 mL 6.4 mL
10 mM 0.32 mL 1.6 mL 3.2 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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References

References are publications that support the biological activity of the product.

Kim et al (2014) Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J.Immunol. 192 110 PMID: 24307733


If you know of a relevant reference for 5J 4, please let us know.

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View all Other Calcium Channel Blockers

Keywords: 5J 4, 5J 4 supplier, 5J4, CRAC, calcium, release, activated, store, operated, entry, SOCE, anti-inflammatory, channels, Ca2+, blockers, Other, Calcium, Channels, STIM-Orai, 5490, Tocris Bioscience

1 Citation for 5J 4

Citations are publications that use Tocris products. Selected citations for 5J 4 include:

Rao et al (2016) Homer1a attenuates glutamate-induced oxidative injury in HT-22 cells through regulation of store-operated calcium entry. Sci Rep 6 33975 PMID: 27681296


Do you know of a great paper that uses 5J 4 from Tocris? Please let us know.

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