5'-Fluoroindirubinoxime

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Cat.No. 4033 - 5'-Fluoroindirubinoxime | C16H10FN3O2 | CAS No. 861214-33-7
Description: FLT3 inhibitor; displays antiproliferative activity
Chemical Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione 3-oxime
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).

Licensing Information

Sold under licence from Anygen Co. Ltd.

Technical Data

M. Wt 295.27
Formula C16H10FN3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 861214-33-7
PubChem ID 11580208
InChI Key LBUXOYSDWHGJNP-UHFFFAOYSA-N
Smiles O=C(NC4=C3C=C(F)C=C4)/C3=C2NC1=CC=CC=C1C/2=NO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 295.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.39 mL 16.93 mL 33.87 mL
5 mM 0.68 mL 3.39 mL 6.77 mL
10 mM 0.34 mL 1.69 mL 3.39 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (2007) Antitumor activity of novel indirubin derivatives in rat tumor model. Clin.Cancer Res. 13 253 PMID: 17200363

Krivogorsky et al (2008) Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. Antimicrob.Agents Chemother. 52 4466 PMID: 18824607

Choi et al (2010) Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg.Med.Chem.Lett. 20 2033 PMID: 20153646


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Keywords: FMS-like receptor tyrosine kinase-3 FLT3 inhibitors inhibits antiproliferative 5-Fluoroindirubinoxime FLT3

Citations for 5'-Fluoroindirubinoxime

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for 5'-Fluoroindirubinoxime

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