4μ8C

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Cat.No. 4479 - 4mu8C | C11H8O4 | CAS No. 14003-96-4
Description: Inhibits IRE1α endoribonuclease activity
Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Purity: ≥98%
Datasheet
Citations (1)
Literature

Biological Activity

Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.

Technical Data

M. Wt 204.18
Formula C11H8O4
Storage Store at -20°C
Purity ≥98%
CAS Number 14003-96-4
PubChem ID 12934390
InChI Key RTHHSXOVIJWFQP-UHFFFAOYSA-N
Smiles CC(C1=CC=C(O)C(C=O)=C1O2)=CC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.42 100
ethanol 2.04 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 204.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.9 mL 24.49 mL 48.98 mL
5 mM 0.98 mL 4.9 mL 9.8 mL
10 mM 0.49 mL 2.45 mL 4.9 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cross et al (2012) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 109 E869 PMID: 22315414


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Keywords: 4mu8C, supplier, 4m8C, 4mu8C, 4μ8C, selective, inhibitors, inhibits, ire1, rnase, endoribonuclease, IRE1, Tocris Bioscience

1 Citation for 4μ8C

Citations are publications that use Tocris products. Selected citations for 4μ8C include:

Beisel (2017) TLR7-mediated activation of XBP1 correlates with the IFN╬▒ production in humans Cytokine 94 55 PMID: 28408069


Do you know of a great paper that uses 4μ8C from Tocris? If so please let us know.

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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