4μ8C

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Cat.No. 4479 - 4mu8C | C11H8O4 | CAS No. 14003-96-4
Description: Inhibits IRE1α endoribonuclease activity
Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Purity: ≥98%
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.

Technical Data

M. Wt 204.18
Formula C11H8O4
Storage Store at -20°C
Purity ≥98%
CAS Number 14003-96-4
PubChem ID 12934390
InChI Key RTHHSXOVIJWFQP-UHFFFAOYSA-N
Smiles CC(C1=CC=C(O)C(C=O)=C1O2)=CC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 204.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.9 mL 24.49 mL 48.98 mL
5 mM 0.98 mL 4.9 mL 9.8 mL
10 mM 0.49 mL 2.45 mL 4.9 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

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References

References are publications that support the biological activity of the product.

Cross et al (2012) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 109 E869 PMID: 22315414


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2 Citations for 4μ8C

Citations are publications that use Tocris products. Selected citations for 4μ8C include:

Beisel (2017) TLR7-mediated activation of XBP1 correlates with the IFNα production in humans Cytokine 94 55 PMID: 28408069

Amin-Wetzel et al (2017) A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response. Cell 171 1625 PMID: 29198525


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Literature in this Area

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