You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 204.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.9 mL||24.49 mL||48.98 mL|
|5 mM||0.98 mL||4.9 mL||9.8 mL|
|10 mM||0.49 mL||2.45 mL||4.9 mL|
|50 mM||0.1 mL||0.49 mL||0.98 mL|
References are publications that support the biological activity of the product.
Cross et al (2012) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 109 E869 PMID: 22315414
If you know of a relevant reference for 4μ8C, please let us know.
View Related Products by Product Action
Keywords: 4mu8C, 4mu8C supplier, 4m8C, 4mu8C, 4μ8C, selective, inhibitors, inhibits, ire1, rnase, endoribonuclease, 4u8c, IRE1, 4479, Tocris Bioscience
2 Citations for 4μ8C
Citations are publications that use Tocris products. Selected citations for 4μ8C include:
Beisel (2017) TLR7-mediated activation of XBP1 correlates with the IFNα production in humans Cytokine 94 55 PMID: 28408069
Amin-Wetzel et al (2017) A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response. Cell 171 1625 PMID: 29198525
Do you know of a great paper that uses 4μ8C from Tocris? Please let us know.
Reviews for 4μ8C
There are currently no reviews for this product. Be the first to review 4μ8C and earn rewards!
Have you used 4μ8C?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image