Home / Pharmacology / Enzymes / Esterases / IRE1 / IRE1 Inhibitors / 4μ8C

4μ8C

Cat. No. 4479 2 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Inhibits IRE1α endoribonuclease activity
Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Purity: ≥98%
Datasheet
Citations (2)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for 4μ8C

4μ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.

Compound Libraries for 4μ8C

4mu8C is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 4μ8C

M. Wt 204.18
Formula C11H8O4
Storage Store at -20°C
Purity ≥98%
CAS Number 14003-96-4
PubChem ID 12934390
InChI Key RTHHSXOVIJWFQP-UHFFFAOYSA-N
Smiles CC(C1=CC=C(O)C(C=O)=C1O2)=CC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 4μ8C

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.42 100

Preparing Stock Solutions for 4μ8C

The following data is based on the product molecular weight 204.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.9 mL 24.49 mL 48.98 mL
5 mM 0.98 mL 4.9 mL 9.8 mL
10 mM 0.49 mL 2.45 mL 4.9 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for 4μ8C

References are publications that support the biological activity of the product.

Cross et al (2012) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 109 E869 PMID: 22315414

If you know of a relevant reference for 4μ8C, please let us know.

View Related Products by Target

View Related Products by Product Action

View all IRE1 Inhibitors

Keywords: 4mu8C, 4mu8C supplier, 4m8C, 4mu8C, 4μ8C, selective, inhibitors, inhibits, ire1, rnase, endoribonuclease, 4u8c, IRE1, 4479, Tocris Bioscience

2 Citations for 4μ8C

Citations are publications that use Tocris products. Selected citations for 4μ8C include:

Beisel (2017) TLR7-mediated activation of XBP1 correlates with the IFNα production in humans Cytokine 94 55 PMID: 28408069

Amin-Wetzel et al (2017) A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response. Cell 171 1625 PMID: 29198525

Do you know of a great paper that uses 4μ8C from Tocris? Please let us know.

Reviews for 4μ8C

There are currently no reviews for this product. Be the first to review 4μ8C and earn rewards!

Have you used 4μ8C?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets