4μ8C

Pricing Availability   Qty
Description: Inhibits IRE1α endoribonuclease activity
Chemical Name: 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Purity: ≥98%
Datasheet
Citations (10)
Reviews
Literature (1)

Biological Activity for 4μ8C

4μ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Blocks substrate access to the active site of IRE1α. Inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.

Compound Libraries for 4μ8C

4mu8C is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 4μ8C

M. Wt 204.18
Formula C11H8O4
Storage Store at -20°C
Purity ≥98%
CAS Number 14003-96-4
PubChem ID 12934390
InChI Key RTHHSXOVIJWFQP-UHFFFAOYSA-N
Smiles CC(C1=CC=C(O)C(C=O)=C1O2)=CC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 4μ8C

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.42 100

Preparing Stock Solutions for 4μ8C

The following data is based on the product molecular weight 204.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.9 mL 24.49 mL 48.98 mL
5 mM 0.98 mL 4.9 mL 9.8 mL
10 mM 0.49 mL 2.45 mL 4.9 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

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References for 4μ8C

References are publications that support the biological activity of the product.

Cross et al (2012) The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc.Natl.Acad.Sci.USA 109 E869 PMID: 22315414


If you know of a relevant reference for 4μ8C, please let us know.

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Keywords: 4mu8C, 4mu8C supplier, 4m8C, 4mu8C, 4μ8C, selective, inhibitors, inhibits, ire1, rnase, endoribonuclease, 4u8c, IRE1, 4479, Tocris Bioscience

10 Citations for 4μ8C

Citations are publications that use Tocris products. Selected citations for 4μ8C include:

Mart et al (2021) The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor. J Biol Chem 296 100295 PMID: 33460650

Lisa G M et al (2022) Saponin-based adjuvant-induced dendritic cell cross-presentation is dependent on PERK activation. Cell Mol Life Sci 79 231 PMID: 35396971

Li-ying et al (2022) CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival. Int J Mol Sci 23 PMID: 36012764

Judith A et al (2019) Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis. Sci Transl Med 11 PMID: 30728287


Do you know of a great paper that uses 4μ8C from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 170 products, including research tools for:

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