4-PPBP maleate

Pricing Availability Delivery Time Qty
Cat.No. 0620 - 4-PPBP maleate | C21H27N.C4H4O4 | CAS No. 201216-39-9
Description: Specific σ ligand, NMDA antagonist
Chemical Name: 4-Phenyl-1-(4-phenylbutyl)piperidine maleate
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

σ ligand and selective non-competitive antagonist at recombinant NR1a/2B NMDA receptors expressed in Xenopus oocytes.

Compound Libraries

4-PPBP maleate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 409.52
Formula C21H27N.C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 201216-39-9
PubChem ID 11682970
Smiles OC(=O)\C=C/C(O)=O.C(CCC1=CC=CC=C1)CN1CCC(CC1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 10.24 25
ethanol 10.24 25

Preparing Stock Solutions

The following data is based on the product molecular weight 409.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Glennon et al (1991) Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high affinity σ ligands. J.Med.Chem. 34 3360 PMID: 1662725

Whittemore et al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571

If you know of a relevant reference for 4-PPBP maleate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Sigma-Related Ligands

Keywords: 4-PPBP maleate, supplier, Specific, σ, sigma, ligand, NMDA, antagonists, Receptors, Sigma-Related, Sigma-Related, Tocris Bioscience

1 Citation for 4-PPBP maleate

Citations are publications that use Tocris products. Selected citations for 4-PPBP maleate include:

Yang et al (2007) σ receptor agonists provide neuroprotection in vitro by preserving bcl-2. Front Behav Neurosci 104 1179 PMID: 17456670

Do you know of a great paper that uses 4-PPBP maleate from Tocris? If so please let us know.

Reviews for 4-PPBP maleate

There are currently no reviews for this product. Be the first to review 4-PPBP maleate and earn rewards!

Have you used 4-PPBP maleate?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells