4-PPBP maleate

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Cat.No. 0620 - 4-PPBP maleate | C21H27N.C4H4O4 | CAS No. 201216-39-9
Description: Specific σ ligand, NMDA antagonist
Chemical Name: 4-Phenyl-1-(4-phenylbutyl)piperidine maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

σ ligand and selective non-competitive antagonist at recombinant NR1a/2B NMDA receptors expressed in Xenopus oocytes.

Compound Libraries

4-PPBP maleate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 409.52
Formula C21H27N.C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 201216-39-9
PubChem ID 11682970
InChI Key OASPNIMFGJVLES-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.C(CCC1=CC=CC=C1)CN1CCC(CC1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.24 25
ethanol 10.24 25

Preparing Stock Solutions

The following data is based on the product molecular weight 409.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Glennon et al (1991) Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high affinity σ ligands. J.Med.Chem. 34 3360 PMID: 1662725

Whittemore et al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571


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View all Sigma-Related Ligands

Keywords: Specific σ sigma ligand NMDA antagonists Receptors Sigma-Related

1 Citation for 4-PPBP maleate

Citations are publications that use Tocris products. Selected citations for 4-PPBP maleate include:

Yang et al (2007) σ receptor agonists provide neuroprotection in vitro by preserving bcl-2. Front Behav Neurosci 104 1179 PMID: 17456670


Do you know of a great paper that uses 4-PPBP maleate from Tocris? If so please let us know.

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