4-PPBP maleate

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Description: Specific σ ligand, NMDA antagonist
Chemical Name: 4-Phenyl-1-(4-phenylbutyl)piperidine maleate
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for 4-PPBP maleate

4-PPBP maleate is a σ ligand and selective non-competitive antagonist at recombinant NR1a/2B NMDA receptors expressed in Xenopus oocytes.

Technical Data for 4-PPBP maleate

M. Wt 409.52
Formula C21H27N.C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 201216-39-9
PubChem ID 11682970
Smiles OC(=O)\C=C/C(O)=O.C(CCC1=CC=CC=C1)CN1CCC(CC1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 4-PPBP maleate

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 10.24 25
DMSO 10.24 25

Preparing Stock Solutions for 4-PPBP maleate

The following data is based on the product molecular weight 409.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.77 mL 48.84 mL 97.68 mL
1.25 mM 1.95 mL 9.77 mL 19.54 mL
2.5 mM 0.98 mL 4.88 mL 9.77 mL
12.5 mM 0.2 mL 0.98 mL 1.95 mL

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Product Datasheets for 4-PPBP maleate

References for 4-PPBP maleate

References are publications that support the biological activity of the product.

Glennon et al (1991) Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high affinity σ ligands. J.Med.Chem. 34 3360 PMID: 1662725

Whittemore et al (1997) Antagonism of N-MthD.-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326 PMID: 9223571

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Keywords: 4-PPBP maleate, 4-PPBP maleate supplier, Specific, σ, sigma, ligand, NMDA, antagonists, Receptors, Sigma-Related, 0620, Tocris Bioscience

1 Citation for 4-PPBP maleate

Citations are publications that use Tocris products. Selected citations for 4-PPBP maleate include:

Yang et al (2007) σ receptor agonists provide neuroprotection in vitro by preserving bcl-2. Front Behav Neurosci 104 1179 PMID: 17456670

Do you know of a great paper that uses 4-PPBP maleate from Tocris? Please let us know.

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