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Inhibitor of release of dopamine induced by methamphetamine.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 245.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||16.28 mL||81.38 mL||162.77 mL|
|1.25 mM||3.26 mL||16.28 mL||32.55 mL|
|2.5 mM||1.63 mL||8.14 mL||16.28 mL|
|12.5 mM||0.33 mL||1.63 mL||3.26 mL|
References are publications that support the biological activity of the product.
Tateyama et al (1993) 4-Phenyltetrahydroisoquinoline, but not nomifensine or cocaine, inhibits methamphetamine-induced DA release. Eur.J.Pharmacol. 240 51 PMID: 8405121
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Keywords: 4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride, 4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride supplier, DA, release, inhibitors, inhibits, Dopaminergic, Dopamine, Receptors, Dopaminergic-Related, 0730, Tocris Bioscience
Citations for 4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.