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Description: MT2 antagonist
Alternative Names: AH 024
Chemical Name: cis-4-Phenyl-2-propionamidotetralin
Purity: ≥99% (HPLC)
Citations (8)

Biological Activity for 4-P-PDOT

4-P-PDOT is a melatonin receptor antagonist, >300-fold selective for the MT2 (vs MT1) subtype.

Compound Libraries for 4-P-PDOT

4-P-PDOT is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 4-P-PDOT

M. Wt 279.38
Formula C19H21NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 620170-78-7
PubChem ID 3976006
Smiles CCC(=O)NC1CC(C2=CC=CC=C2)C2=C(C1)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 4-P-PDOT

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.94 100
ethanol 27.94 100

Preparing Stock Solutions for 4-P-PDOT

The following data is based on the product molecular weight 279.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.9 mL 35.79 mL
5 mM 0.72 mL 3.58 mL 7.16 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets for 4-P-PDOT

Certificate of Analysis / Product Datasheet
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References for 4-P-PDOT

References are publications that support the biological activity of the product.

Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365 PMID: 9089668

Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083

If you know of a relevant reference for 4-P-PDOT, please let us know.

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Keywords: 4-P-PDOT, 4-P-PDOT supplier, MT2, antagonists, Receptors, Melatonin, AH024, AH, 024, (MT), 1034, Tocris Bioscience

8 Citations for 4-P-PDOT

Citations are publications that use Tocris products. Selected citations for 4-P-PDOT include:

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Pharmacol Exp Ther 336 127 PMID: 20959363

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. J Clin Invest 20 1298 PMID: 24574803

Hou et al (2017) Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci 11 98 PMID: 28473754

Zhao et al (2010) Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. J Physiol 588 2605 PMID: 20519319

Do you know of a great paper that uses 4-P-PDOT from Tocris? Please let us know.

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