Melatonin receptor antagonist, >300-fold selective for the MT2 (vs MT1) subtype.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 279.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.58 mL||17.9 mL||35.79 mL|
|5 mM||0.72 mL||3.58 mL||7.16 mL|
|10 mM||0.36 mL||1.79 mL||3.58 mL|
|50 mM||0.07 mL||0.36 mL||0.72 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365 PMID: 9089668
Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083
If you know of a relevant reference for 4-P-PDOT, please let us know.
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Keywords: MT2 antagonists Receptors Melatonin AH024 AH 024 Melatonin (MT) Receptors
5 Citations for 4-P-PDOT
Citations are publications that use Tocris products. Selected citations for 4-P-PDOT include:
Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Pharmacol Exp Ther 336 127 PMID: 20959363
Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141
Danilova et al (2004) Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development. J Pharmacol Exp Ther 18 751 PMID: 14766799
Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. FASEB J 108 625 PMID: 11518737
Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. J Clin Invest 20 1298 PMID: 24574803
Do you know of a great paper that uses 4-P-PDOT from Tocris? If so please let us know.