4-P-PDOT

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Cat.No. 1034 - 4-P-PDOT | C19H21NO | CAS No. 620170-78-7
Description: MT2 antagonist
Alternative Names: AH 024
Chemical Name: cis-4-Phenyl-2-propionamidotetralin
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Melatonin receptor antagonist, >300-fold selective for the MT2 (vs MT1) subtype.

Compound Libraries

4-P-PDOT is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 279.38
Formula C19H21NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 620170-78-7
PubChem ID 3976006
InChI Key RCYLUNPFECYGDW-UHFFFAOYSA-N
Smiles CCC(=O)NC1CC(C2=CC=CC=C2)C2=C(C1)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.94 100
ethanol 27.94 100

Preparing Stock Solutions

The following data is based on the product molecular weight 279.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.9 mL 35.79 mL
5 mM 0.72 mL 3.58 mL 7.16 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365 PMID: 9089668

Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083


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View Related Products by Target

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Keywords: 4-P-PDOT, supplier, MT2, antagonists, Receptors, Melatonin, AH024, AH, 024, Melatonin, (MT), Receptors, Melatonin, (MT), Receptors, Tocris Bioscience

5 Citations for 4-P-PDOT

Citations are publications that use Tocris products. Selected citations for 4-P-PDOT include:

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. J Clin Invest 20 1298 PMID: 24574803

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Pharmacol Exp Ther 336 127 PMID: 20959363

Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478 PMID: 20696141

Danilova et al (2004) Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development. J Pharmacol Exp Ther 18 751 PMID: 14766799

Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. FASEB J 108 625 PMID: 11518737


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