4-P-PDOT

Pricing Availability   Qty
Description: MT2 antagonist
Alternative Names: AH 024
Chemical Name: cis-4-Phenyl-2-propionamidotetralin
Purity: ≥99% (HPLC)
Datasheet
Citations (8)
Reviews

Biological Activity for 4-P-PDOT

4-P-PDOT is a melatonin receptor antagonist, >300-fold selective for the MT2 (vs MT1) subtype.

Compound Libraries for 4-P-PDOT

4-P-PDOT is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 4-P-PDOT

M. Wt 279.38
Formula C19H21NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 620170-78-7
PubChem ID 3976006
InChI Key RCYLUNPFECYGDW-UHFFFAOYSA-N
Smiles CCC(=O)NC1CC(C2=CC=CC=C2)C2=C(C1)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 4-P-PDOT

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.94 100
ethanol 27.94 100

Preparing Stock Solutions for 4-P-PDOT

The following data is based on the product molecular weight 279.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.9 mL 35.79 mL
5 mM 0.72 mL 3.58 mL 7.16 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets for 4-P-PDOT

Certificate of Analysis / Product Datasheet
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References for 4-P-PDOT

References are publications that support the biological activity of the product.

Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365 PMID: 9089668

Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083


If you know of a relevant reference for 4-P-PDOT, please let us know.

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Keywords: 4-P-PDOT, 4-P-PDOT supplier, MT2, antagonists, Receptors, Melatonin, AH024, AH, 024, (MT), 1034, Tocris Bioscience

8 Citations for 4-P-PDOT

Citations are publications that use Tocris products. Selected citations for 4-P-PDOT include:

Chen et al (2014) Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. J Clin Invest 20 1298 PMID: 24574803

Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. FASEB J 108 625 PMID: 11518737

Faria et al (2013) Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats. Am J Physiol Endocrinol Metab 305 E230 PMID: 23695212

Danilova et al (2004) Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development. J Pharmacol Exp Ther 18 751 PMID: 14766799


Do you know of a great paper that uses 4-P-PDOT from Tocris? Please let us know.

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