4-Methylhistamine dihydrochloride

Pricing Availability   Qty
Description: Selective, high affinity H4 agonist
Chemical Name: 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride
Citations (4)
Literature (1)

Biological Activity for 4-Methylhistamine dihydrochloride

4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

Technical Data for 4-Methylhistamine dihydrochloride

M. Wt 198.09
Formula C6H11N3.2HCl
Storage Desiccate at RT
CAS Number 36376-47-3
PubChem ID 215819
Smiles Cl.Cl.CC1=C(CCN)NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 4-Methylhistamine dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 246.8 50

Preparing Stock Solutions for 4-Methylhistamine dihydrochloride

The following data is based on the product molecular weight 198.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 10.1 mL 50.48 mL 100.96 mL
2.5 mM 2.02 mL 10.1 mL 20.19 mL
5 mM 1.01 mL 5.05 mL 10.1 mL
25 mM 0.2 mL 1.01 mL 2.02 mL

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Product Datasheets for 4-Methylhistamine dihydrochloride

References for 4-Methylhistamine dihydrochloride

References are publications that support the biological activity of the product.

Lim et al (2005) Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J.Pharmacol.Exp.Ther. 314 1310 PMID: 15947036

Gbahou et al (2006) Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol 147 74

If you know of a relevant reference for 4-Methylhistamine dihydrochloride, please let us know.

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Keywords: 4-Methylhistamine dihydrochloride, 4-Methylhistamine dihydrochloride supplier, Selective, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, 2342, Tocris Bioscience

4 Citations for 4-Methylhistamine dihydrochloride

Citations are publications that use Tocris products. Selected citations for 4-Methylhistamine dihydrochloride include:

Desmadryl et al (2012) Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability. Br J Pharmacol 167 905 PMID: 22624822

Connelly et al (2009) The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol 157 55 PMID: 19413571

Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Bone Joint Res 152 891 PMID: 17891168

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477

Do you know of a great paper that uses 4-Methylhistamine dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.