4-Methylhistamine dihydrochloride

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Cat.No. 2342 - 4-Methylhistamine dihydrochloride | C6H11N3.2HCl | CAS No. 36376-47-3
Description: Selective, high affinity H4 agonist
Chemical Name: 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

Technical Data

M. Wt 198.09
Formula C6H11N3.2HCl
Storage Desiccate at RT
CAS Number 36376-47-3
PubChem ID 215819
InChI Key BVJIXYJOFWYOBL-UHFFFAOYSA-N
Smiles Cl.Cl.CC1=C(CCN)NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 246.8 50

Preparing Stock Solutions

The following data is based on the product molecular weight 198.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.05 mL 25.24 mL 50.48 mL
5 mM 1.01 mL 5.05 mL 10.1 mL
10 mM 0.5 mL 2.52 mL 5.05 mL
50 mM 0.1 mL 0.5 mL 1.01 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Lim et al (2005) Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J.Pharmacol.Exp.Ther. 314 1310 PMID: 15947036

Gbahou et al (2006) Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol 147 74


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Keywords: 4-Methylhistamine dihydrochloride, 4-Methylhistamine dihydrochloride supplier, Selective, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, 2342, Tocris Bioscience

4 Citations for 4-Methylhistamine dihydrochloride

Citations are publications that use Tocris products. Selected citations for 4-Methylhistamine dihydrochloride include:

Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Bone Joint Res 152 891 PMID: 17891168

Desmadryl et al (2012) Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability. Br J Pharmacol 167 905 PMID: 22624822

Connelly et al (2009) The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol 157 55 PMID: 19413571

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477


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