Potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 198.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.05 mL||25.24 mL||50.48 mL|
|5 mM||1.01 mL||5.05 mL||10.1 mL|
|10 mM||0.5 mL||2.52 mL||5.05 mL|
|50 mM||0.1 mL||0.5 mL||1.01 mL|
References are publications that support the products' biological activity.
Lim et al (2005) Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J.Pharmacol.Exp.Ther. 314 1310 PMID: 15947036
If you know of a relevant reference for 4-Methylhistamine dihydrochloride, please let us know.
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Keywords: 4-Methylhistamine dihydrochloride, supplier, Selective, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, Histamine, H4, Receptors, Histamine, H4, Receptors, Tocris Bioscience
4 Citations for 4-Methylhistamine dihydrochloride
Citations are publications that use Tocris products. Selected citations for 4-Methylhistamine dihydrochloride include:
Connelly et al (2009) The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol 157 55 PMID: 19413571
Desmadryl et al (2012) Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability. Br J Pharmacol 167 905 PMID: 22624822
Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477
Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Bone Joint Res 152 891 PMID: 17891168
Do you know of a great paper that uses 4-Methylhistamine dihydrochloride from Tocris? If so please let us know.
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Literature in this Area
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