4-Methylhistamine dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 2342 - 4-Methylhistamine dihydrochloride | C6H11N3.2HCl | CAS No. 36376-47-3
Description: Selective, high affinity H4 agonist
Chemical Name: 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride
Citations (2)

Biological Activity

Potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

Technical Data

M. Wt 198.09
Formula C6H11N3.2HCl
Storage Desiccate at RT
CAS Number 36376-47-3
PubChem ID 215819
Smiles Cl.Cl.CC1=C(CCN)NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 246.8 50

Preparing Stock Solutions

The following data is based on the product molecular weight 198.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.05 mL 25.24 mL 50.48 mL
5 mM 1.01 mL 5.05 mL 10.1 mL
10 mM 0.5 mL 2.52 mL 5.05 mL
50 mM 0.1 mL 0.5 mL 1.01 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Lim et al (2005) Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J.Pharmacol.Exp.Ther. 314 1310 PMID: 15947036

Gbahou et al (2006) Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol 147 74 PMID:

If you know of a relevant reference for 4-Methylhistamine dihydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Histamine H4 Receptor Agonists

Keywords: 4-Methylhistamine dihydrochloride, supplier, Selective, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, Histamine, H4, Receptors, Histamine, H4, Receptors, Tocris Bioscience

2 Citations for 4-Methylhistamine dihydrochloride

Citations are publications that use Tocris products. Selected citations for 4-Methylhistamine dihydrochloride include:

Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Bone Joint Res 152 891 PMID: 17891168

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477

Do you know of a great paper that uses 4-Methylhistamine dihydrochloride from Tocris? If so please let us know.

Reviews for 4-Methylhistamine dihydrochloride

There are currently no reviews for this product. Be the first to review 4-Methylhistamine dihydrochloride and earn rewards!

Have you used 4-Methylhistamine dihydrochloride?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Histamine Receptors

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.


Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.