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Biological Activity for 4-Methylhistamine dihydrochloride
4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.
Technical Data for 4-Methylhistamine dihydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 4-Methylhistamine dihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for 4-Methylhistamine dihydrochloride
The following data is based on the product molecular weight 198.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||10.1 mL||50.48 mL||100.96 mL|
|2.5 mM||2.02 mL||10.1 mL||20.19 mL|
|5 mM||1.01 mL||5.05 mL||10.1 mL|
|25 mM||0.2 mL||1.01 mL||2.02 mL|
Product Datasheets for 4-Methylhistamine dihydrochloride
References for 4-Methylhistamine dihydrochloride
References are publications that support the biological activity of the product.
Lim et al (2005) Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J.Pharmacol.Exp.Ther. 314 1310 PMID: 15947036
Gbahou et al (2006) Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol 147 74
If you know of a relevant reference for 4-Methylhistamine dihydrochloride, please let us know.
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Keywords: 4-Methylhistamine dihydrochloride, 4-Methylhistamine dihydrochloride supplier, Selective, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, 2342, Tocris Bioscience
4 Citations for 4-Methylhistamine dihydrochloride
Citations are publications that use Tocris products. Selected citations for 4-Methylhistamine dihydrochloride include:
Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149 PMID: 23626477
Holden et al (2007) Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells. Bone Joint Res 152 891 PMID: 17891168
Desmadryl et al (2012) Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability. Br J Pharmacol 167 905 PMID: 22624822
Connelly et al (2009) The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol 157 55 PMID: 19413571
Do you know of a great paper that uses 4-Methylhistamine dihydrochloride from Tocris? Please let us know.
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Literature in this Area
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