Free fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 294.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.39 mL||16.96 mL||33.92 mL|
|5 mM||0.68 mL||3.39 mL||6.78 mL|
|10 mM||0.34 mL||1.7 mL||3.39 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Smith et al (2011) Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol.Pharmacol. 80 163 PMID: 21498659
Milligan et al (2009) Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br.J.Pharmacol. 158 146 PMID: 19719777
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Keywords: free fatty acid receptors FFA FFA2 agonists positive allosteric modulators pams Free Fatty Acid Receptors
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