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Free fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 294.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.39 mL||16.96 mL||33.92 mL|
|5 mM||0.68 mL||3.39 mL||6.78 mL|
|10 mM||0.34 mL||1.7 mL||3.39 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
References are publications that support the biological activity of the product.
Smith et al (2011) Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol.Pharmacol. 80 163 PMID: 21498659
Milligan et al (2009) Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br.J.Pharmacol. 158 146 PMID: 19719777
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Keywords: 4-CMTB, 4-CMTB supplier, free, fatty, acid, receptors, FFA, FFA2, agonists, positive, allosteric, modulators, pams, Free, Fatty, Acid, Receptors, 4642, Tocris Bioscience
3 Citations for 4-CMTB
Citations are publications that use Tocris products. Selected citations for 4-CMTB include:
Marinelli et al (2019) Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells Sci.Rep. 9 643 PMID: 30679727
Martin-Gallausiaux et al (2019) Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol 9 2838 PMID: 30619249
Martin-Gallausiaux et al (2018) Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells. Sci Rep 8 9742 PMID: 29950699
Do you know of a great paper that uses 4-CMTB from Tocris? Please let us know.
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Literature in this Area
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