4-CMTB

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Cat.No. 4642 - 4-CMTB | C14H15ClN2OS | CAS No. 300851-67-6
Description: FFA2 agonist; also exhibits positive allosteric modulatory activity
Chemical Name: 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Free fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).

Compound Libraries

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Technical Data

M. Wt 294.8
Formula C14H15ClN2OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 300851-67-6
PubChem ID 4307629
InChI Key AZYDQCGCBQYFSE-UHFFFAOYSA-N
Smiles ClC1=CC=C(C(C(C)C)C(NC2=NC=CS2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.48 100
ethanol 5.9 20

Preparing Stock Solutions

The following data is based on the product molecular weight 294.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.39 mL 16.96 mL 33.92 mL
5 mM 0.68 mL 3.39 mL 6.78 mL
10 mM 0.34 mL 1.7 mL 3.39 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References

References are publications that support the biological activity of the product.

Smith et al (2011) Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol.Pharmacol. 80 163 PMID: 21498659

Milligan et al (2009) Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br.J.Pharmacol. 158 146 PMID: 19719777


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Keywords: 4-CMTB, 4-CMTB supplier, free, fatty, acid, receptors, FFA, FFA2, agonists, positive, allosteric, modulators, pams, Free, Fatty, Acid, Receptors, 4642, Tocris Bioscience

3 Citations for 4-CMTB

Citations are publications that use Tocris products. Selected citations for 4-CMTB include:

Marinelli et al (2019) Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells Sci.Rep. 9 643 PMID: 30679727

Martin-Gallausiaux et al (2019) Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol 9 2838 PMID: 30619249

Martin-Gallausiaux et al (2018) Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells. Sci Rep 8 9742 PMID: 29950699


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Literature in this Area

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