4-CMTB

Pricing Availability Delivery Time Qty
Cat.No. 4642 - 4-CMTB | C14H15ClN2OS | CAS No. 300851-67-6
Description: FFA2 agonist; also exhibits positive allosteric modulatory activity
Chemical Name: 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Free fatty acid receptor FFA2 agonist (pEC50 = 6.38) and positive allosteric modulator. Binds at a site distinct from the orthosteric site; modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2).

Compound Libraries

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Technical Data

M. Wt 294.8
Formula C14H15ClN2OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 300851-67-6
PubChem ID 4307629
InChI Key AZYDQCGCBQYFSE-UHFFFAOYSA-N
Smiles ClC1=CC=C(C(C(C)C)C(NC2=NC=CS2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.48 100
ethanol 5.9 20

Preparing Stock Solutions

The following data is based on the product molecular weight 294.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.39 mL 16.96 mL 33.92 mL
5 mM 0.68 mL 3.39 mL 6.78 mL
10 mM 0.34 mL 1.7 mL 3.39 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Smith et al (2011) Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol.Pharmacol. 80 163 PMID: 21498659

Milligan et al (2009) Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br.J.Pharmacol. 158 146 PMID: 19719777


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Keywords: free fatty acid receptors FFA FFA2 agonists positive allosteric modulators pams Free Fatty Acid Receptors

Citations for 4-CMTB

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Literature in this Area

GPCR

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Pathways for 4-CMTB

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