3-MPPI

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Cat.No. 0581 - 3-MPPI | C23H25N5O3 | CAS No. 133399-65-2
Description: α1 ligand
Chemical Name: 2-[(4-Phenylpiperazin-1-yl)methyl]-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one
Datasheet
Citations
Literature

Biological Activity

Very potent ligand for α1 sites (Ki for displacement of prazosin = 0.2 nM). Displays different binding properties for each α1 subtype (pKi values are 8.74, 9.44 and 9.57 for α1B, α1D and α1A adrenoceptors respectively). Also binds to 5-HT1A sites (Ki = 50 nM).

Technical Data

M. Wt 419.48
Formula C23H25N5O3
Storage Store at RT
CAS Number 133399-65-2
PubChem ID 4013695
InChI Key AQASGOHUMGAWJJ-UHFFFAOYSA-N
Smiles COC1=C(C=CC=C1)N1CCN(CCN2C(=O)NC3=C(NC4=CC=CC=C34)C2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.19 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 419.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.84 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Russo et al (1991) Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective α1 adrenoceptor ligands. J.Med.Chem. 34 1850 PMID: 1648138

Romeo et al (2003) New pyrimido[5,4-b]indoles as ligands for α1-adrenoceptor subtypes. J.Med.Chem. 46 2877 PMID: 12825930


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Citations for 3-MPPI

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Literature in this Area

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Pathways for 3-MPPI

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