3'-Fluorobenzylspiperone maleate

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Cat.No. 0701 - 3'-Fluorobenzylspiperone maleate | C30H31F2N3O2.C4H4O4 | CAS No. 1135278-61-3
Description: D2-like receptor ligand
Chemical Name: 8-[4-(4-Fluorophenyl)-4-oxobutyl]-(3-fluorobenzyl-1-phenyl)-1,3,8-triazaspiro[4,5]decan-4-one maleate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

A very potent and selective ligand for the D2 receptor (Ki = 0.023 nM). Compared with spiperone, displays a 2.5-fold greater affinity at D2 and a 12-fold lower affinity at 5-HT2 receptors.

Compound Libraries

3'-Fluorobenzylspiperone maleate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 619.67
Formula C30H31F2N3O2.C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1135278-61-3
PubChem ID 24978532
InChI Key JURUFADWVGXLOY-BTJKTKAUSA-N
Smiles OC(=O)\C=C/C(O)=O.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CN(CC1=CC=CC(F)=C1)C2=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.49 25

Preparing Stock Solutions

The following data is based on the product molecular weight 619.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.61 mL 8.07 mL 16.14 mL
5 mM 0.32 mL 1.61 mL 3.23 mL
10 mM 0.16 mL 0.81 mL 1.61 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mach et al (1992) Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors. J.Med.Chem. 35 423 PMID: 1531364


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Keywords: D2-like ligand Dopamine Non-Selective Receptors dopaminergic 3-Fluorobenzylspiperone maleate Non-selective Dopamine

Citations for 3'-Fluorobenzylspiperone maleate

Citations are publications that use Tocris products.

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Pathways for 3'-Fluorobenzylspiperone maleate

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