3'-Fluorobenzylspiperone maleate
Biological Activity
A very potent and selective ligand for the D2 receptor (Ki = 0.023 nM). Compared with spiperone, displays a 2.5-fold greater affinity at D2 and a 12-fold lower affinity at 5-HT2 receptors.
Compound Libraries
3'-Fluorobenzylspiperone maleate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 619.67 |
| Formula | C30H31F2N3O2.C4H4O4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1135278-61-3 |
| PubChem ID | 24978532 |
| InChI Key | JURUFADWVGXLOY-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CN(CC1=CC=CC(F)=C1)C2=O)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.49 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 619.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.61 mL | 8.07 mL | 16.14 mL |
| 5 mM | 0.32 mL | 1.61 mL | 3.23 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.61 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.32 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Mach et al (1992) Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors. J.Med.Chem. 35 423 PMID: 1531364
If you know of a relevant reference for 3'-Fluorobenzylspiperone maleate, please let us know.
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Keywords: D2-like ligand Dopamine Non-Selective Receptors dopaminergic 3-Fluorobenzylspiperone maleate Non-selective Dopamine
Citations for 3'-Fluorobenzylspiperone maleate
Citations are publications that use Tocris products.
Currently there are no citations for 3'-Fluorobenzylspiperone maleate. Do you know of a great paper that uses 3'-Fluorobenzylspiperone maleate from Tocris? If so please let us know.
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