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Submit Review3'-Fluorobenzylspiperone maleate
Description: D2-like receptor ligand
Chemical Name: 8-[4-(4-Fluorophenyl)-4-oxobutyl]-(3-fluorobenzyl-1-phenyl)-1,3,8-triazaspiro[4,5]decan-4-one maleate
Purity: ≥98% (HPLC)
Biological Activity for 3'-Fluorobenzylspiperone maleate
3'-Fluorobenzylspiperone maleate is a very potent and selective ligand for the D2 receptor (Ki = 0.023 nM). Compared with spiperone, displays a 2.5-fold greater affinity at D2 and a 12-fold lower affinity at 5-HT2 receptors.
Technical Data for 3'-Fluorobenzylspiperone maleate
| M. Wt | 619.67 |
| Formula | C30H31F2N3O2.C4H4O4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1135278-61-3 |
| PubChem ID | 24978532 |
| InChI Key | JURUFADWVGXLOY-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CN(CC1=CC=CC(F)=C1)C2=O)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for 3'-Fluorobenzylspiperone maleate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.49 | 25 |
Preparing Stock Solutions for 3'-Fluorobenzylspiperone maleate
The following data is based on the product molecular weight 619.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 6.46 mL | 32.28 mL | 64.55 mL |
| 1.25 mM | 1.29 mL | 6.46 mL | 12.91 mL |
| 2.5 mM | 0.65 mL | 3.23 mL | 6.46 mL |
| 12.5 mM | 0.13 mL | 0.65 mL | 1.29 mL |
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Product Datasheets for 3'-Fluorobenzylspiperone maleate
References for 3'-Fluorobenzylspiperone maleate
References are publications that support the biological activity of the product.
Mach et al (1992) Effect of N-alkylation on the affinities of analogues of spiperone for DA D2 and serotonin 5-HT2 receptors. J.Med.Chem. 35 423 PMID: 1531364
If you know of a relevant reference for 3'-Fluorobenzylspiperone maleate, please let us know.
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Citations for 3'-Fluorobenzylspiperone maleate
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