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Submit ReviewA very potent and selective ligand for the D2 receptor (Ki = 0.023 nM). Compared with spiperone, displays a 2.5-fold greater affinity at D2 and a 12-fold lower affinity at 5-HT2 receptors.
M. Wt | 619.67 |
Formula | C30H31F2N3O2.C4H4O4 |
Storage | Store at RT |
Purity | ≥98% (HPLC) |
CAS Number | 1135278-61-3 |
PubChem ID | 24978532 |
InChI Key | JURUFADWVGXLOY-BTJKTKAUSA-N |
Smiles | OC(=O)\C=C/C(O)=O.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CN(CC1=CC=CC(F)=C1)C2=O)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 15.49 | 25 |
The following data is based on the product molecular weight 619.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.25 mM | 6.46 mL | 32.28 mL | 64.55 mL |
1.25 mM | 1.29 mL | 6.46 mL | 12.91 mL |
2.5 mM | 0.65 mL | 3.23 mL | 6.46 mL |
12.5 mM | 0.13 mL | 0.65 mL | 1.29 mL |
References are publications that support the biological activity of the product.
Mach et al (1992) Effect of N-alkylation on the affinities of analogues of spiperone for DA D2 and serotonin 5-HT2 receptors. J.Med.Chem. 35 423 PMID: 1531364
If you know of a relevant reference for 3'-Fluorobenzylspiperone maleate, please let us know.
Keywords: 3'-Fluorobenzylspiperone maleate, 3'-Fluorobenzylspiperone maleate supplier, D2-like, ligand, Dopamine, Non-Selective, Receptors, dopaminergic, 3-Fluorobenzylspiperone, maleate, Non-selective, 0701, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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