Pricing Availability Delivery Time Qty
Cat.No. 0666 - 3-AQC | C16H17N5.C4H4O4 | CAS No. 201216-42-4
Description: 5-HT3 antagonist
Chemical Name: 3-(4-Allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate

Biological Activity

A competitive 5-HT3 antagonist, almost 100 times more potent than tropisetron, but with widely differing activity in various tissues.

Technical Data

M. Wt 395.42
Formula C16H17N5.C4H4O4
Storage Desiccate at -20°C
CAS Number 201216-42-4
PubChem ID 11567402
Smiles OC(=O)\C=C/C(O)=O.C=CCN1CCN(CC1)C1=NC2=CC=CC=C2N=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 395.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Buznikov et al (2005) The pre-nervous serotonergic system of developing sea urchin embryos and larvae: pharmacologic and immunocytochemical evidence. Neurochem.Res. 30 825 PMID: 16187217

Durk et al (2005) 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. Int.Immunol. 17 599 PMID: 15802305

Monge et al (1993) Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives. J.Med.Chem. 36 2745 PMID: 8410988

If you know of a relevant reference for 3-AQC, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT3 Receptor Antagonists

Keywords: 3-AQC, supplier, 5-HT3, antagonists, Serotonin, Receptors, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience

Citations for 3-AQC

Citations are publications that use Tocris products.

Currently there are no citations for 3-AQC. Do you know of a great paper that uses 3-AQC from Tocris? If so please let us know.

Reviews for 3-AQC

There are currently no reviews for this product. Be the first to review 3-AQC and earn rewards!

Have you used 3-AQC?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.