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Cat.No. 0666 - 3-AQC | C16H17N5.C4H4O4 | CAS No. 201216-42-4
Description: 5-HT3 antagonist
Chemical Name: 3-(4-Allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate
Literature (2)

Biological Activity

A competitive 5-HT3 antagonist, almost 100 times more potent than tropisetron, but with widely differing activity in various tissues.

Technical Data

M. Wt 395.42
Formula C16H17N5.C4H4O4
Storage Desiccate at -20°C
CAS Number 201216-42-4
PubChem ID 11567402
Smiles OC(=O)\C=C/C(O)=O.C=CCN1CCN(CC1)C1=NC2=CC=CC=C2N=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 395.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.64 mL 25.29 mL
5 mM 0.51 mL 2.53 mL 5.06 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References are publications that support the biological activity of the product.

Buznikov et al (2005) The pre-nervous serotonergic system of developing sea urchin embryos and larvae: pharmacologic and immunocytochemical evidence. Neurochem.Res. 30 825 PMID: 16187217

Durk et al (2005) 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. Int.Immunol. 17 599 PMID: 15802305

Monge et al (1993) Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives. J.Med.Chem. 36 2745 PMID: 8410988

If you know of a relevant reference for 3-AQC, please let us know.

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Keywords: 3-AQC, 3-AQC supplier, 5-HT3, antagonists, Serotonin, Receptors, 0666, Tocris Bioscience

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Ion Channel

Ion Channel Product Listing

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.