Discontinued Product

3-[2-[4-(2-Chlorophenyl)piperazin-1-yl]ethyl]pyrimido[5,4-b]indole-2,4-dione (Cat. No. 0451) has been withdrawn from sale for commercial reasons.
Description: a1 ligand and s2 ligand
Literature (1)

Biological Activity

Potent and extremely selective ligand for α1 sites (Ki = 0.5 nM). At least 200,000-fold selective for α1 over α2, β2 or 5-HT1A receptors.

Technical Data

M. Wt 423.9
Storage Store at RT
CAS Number 133399-68-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service


References are publications that support the biological activity of the product.

Russo et al (1991) Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective α1 adrenoceptor ligands. J.Med.Chem. 34 1850 PMID: 1648138

View Related Products by Target

View Related Products by Product Action

View all Adrenergic α1 Receptor Ligands

Keywords: 3-[2-[4-(2-Chlorophenyl)piperazin-1-yl]ethyl]pyrimido[5,4-b]indole-2,4-dione, 3-[2-[4-(2-Chlorophenyl)piperazin-1-yl]ethyl]pyrimido[5,4-b]indole-2,4-dione supplier, Adrenergic, Alpha-1, Receptors, 0451, Tocris Bioscience

Citations for 3-[2-[4-(2-Chlorophenyl)piperazin-1-yl]ethyl]pyrimido[5,4-b]indole-2,4-dione

Citations are publications that use Tocris products.

Currently there are no citations for 3-[2-[4-(2-Chlorophenyl)piperazin-1-yl]ethyl]pyrimido[5,4-b]indole-2,4-dione.

Reviews for 3-[2-[4-(2-Chlorophenyl)piperazin-1-yl]ethyl]pyrimido[5,4-b]indole-2,4-dione

There are currently no reviews for this product. Be the first to review 3-[2-[4-(2-Chlorophenyl)piperazin-1-yl]ethyl]pyrimido[5,4-b]indole-2,4-dione and earn rewards!

Have you used 3-[2-[4-(2-Chlorophenyl)piperazin-1-yl]ethyl]pyrimido[5,4-b]indole-2,4-dione?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.