26RFa

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Cat.No. 4402 - 26RFa | Val-Gly-Thr-Ala-Leu-Gly-Ser-Leu-Ala-Glu-Glu-Leu-Asn-Gly-Tyr-Asn-Arg-Lys-Lys-Gly-Gly-Phe-Ser-Phe-Arg-Phe-NH2 | CAS No. 881640-56-8
Description: Ligand of GPR103; orexigenic neuropeptide
Alternative Names: P518, QRFP
Datasheet
Citations
Reviews
Literature

Biological Activity

Hypothalamic RFamide-related neuropeptide. Acts as a natural ligand of the orphan receptor GPR103. Exhibits orexigenic acitivity in mice upon central administration.

Technical Data

M. Wt 2818.18
Formula C127H197N37O36
Sequence VGTALGSLAEELNGYNRKKGGFSFRF

(Modifications: Phe-26 = C-terminal amide)

Storage Store at -20°C
CAS Number 881640-56-8
PubChem ID 90488938
InChI Key QPWYMHBRJDWMIS-AULSSRMGSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2818.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.35 mL 1.77 mL 3.55 mL
5 mM 0.07 mL 0.35 mL 0.71 mL
10 mM 0.04 mL 0.18 mL 0.35 mL
50 mM 0.01 mL 0.04 mL 0.07 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kampe et al (2006) Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat. Brain Res. 1119 133 PMID: 16996040

Le Marec et al (2011) Structure-activity relationships of a series of analogues of the RFamide-related peptide 26RFa J.Med.Chem. 54 4806 PMID: 21623631

Chartrel et al (2003) Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc.Natl.Acad.Sci.USA 100 15247 PMID: 14657341


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