25-Hydroxycholesterol

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Cat.No. 5741 - 25-Hydroxycholesterol | C27H46O2 | CAS No. 2140-46-7
Description: Antiviral; also α-crystallin (cryAB) chaperone
Chemical Name: Cholest-5-ene-3β,25-diol
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antiviral. Stimulates expression of miR-185 microRNA which inhibits the hepatitis C virus life cycle via inhibition of cholesterol biosynthesis and virus cell membrane fusion. Also α-crystallin (cryAB) chaperone (Kd = 10.1 μM). Blocks α-crystallin aggregation and partially reverses cataract formation by binding and stabilizing soluble forms of cryAB in vitro and in vivo.

Technical Data

M. Wt 402.65
Formula C27H46O2
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2140-46-7
PubChem ID 65094
InChI Key INBGSXNNRGWLJU-ZHHJOTBYSA-N
Smiles O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)(O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.03 10mM with gentle warming
ethanol 20.13 50

Preparing Stock Solutions

The following data is based on the product molecular weight 402.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.42 mL 24.84 mL
5 mM 0.5 mL 2.48 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Singaravelu et al (2015) MicroRNAs regulate the immunometabolic response to viral infection in the liver. Nat.Chem.Biol. 11 988 PMID: 26479438

Makley et al (2015) Pharmacological chaperone for alpha-crystallin partially restores transparency in cataract models. Science 350 674 PMID: 6542570


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Keywords: 25-Hydroxycholesterol, supplier, Antiviral, alpha-crystallin, chaperone, a-crystallin, α-crystallin, microRNA, miR-185, hepatitis, C, virus, HCV, cholesterol, aggregation, cataract, cryAB, cryAA, amyloid, Antivirals, Antivirals, Tocris Bioscience

Citations for 25-Hydroxycholesterol

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