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Antiviral. Stimulates expression of miR-185 microRNA which inhibits the hepatitis C virus life cycle via inhibition of cholesterol biosynthesis and virus cell membrane fusion. Also α-crystallin (cryAB) chaperone (Kd = 10.1 μM). Blocks α-crystallin aggregation and partially reverses cataract formation by binding and stabilizing soluble forms of cryAB in vitro and in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 402.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.42 mL||62.09 mL||124.18 mL|
|1 mM||2.48 mL||12.42 mL||24.84 mL|
|2 mM||1.24 mL||6.21 mL||12.42 mL|
|10 mM||0.25 mL||1.24 mL||2.48 mL|
References are publications that support the biological activity of the product.
Singaravelu et al (2015) MicroRNAs regulate the immunometabolic response to viral infection in the liver. Nat.Chem.Biol. 11 988 PMID: 26479438
Makley et al (2015) Pharmacological chaperone for alpha-crystallin partially restores transparency in cataract models. Science 350 674 PMID: 26542570
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Keywords: 25-Hydroxycholesterol, 25-Hydroxycholesterol supplier, Antiviral, alpha-crystallin, chaperone, a-crystallin, α-crystallin, microRNA, miR-185, hepatitis, C, virus, HCV, cholesterol, aggregation, cataract, cryAB, cryAA, amyloid, Antivirals, Hepatitis, Viruses, 5741, Tocris Bioscience
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