Metabolically stable analog of adenosine that behaves as an adenosine receptor agonist (Ki values are 300, 80 and 1900 nM for A1, A2A and A3 receptors respectively). Anticonvulsive in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 301.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.31 mL||16.57 mL||33.15 mL|
|5 mM||0.66 mL||3.31 mL||6.63 mL|
|10 mM||0.33 mL||1.66 mL||3.31 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
References are publications that support the products' biological activity.
Mathot et al (1996) Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo. Br.J.Pharmacol. 118 369 PMID: 8735640
Pourgholami et al (1997) Intra-amygdala infusion of 2-chloroadenosine suppresses amygdala-kindled seizures. Brain Res. 775 37 PMID: 9439826
Abdul-Ghani et al (1997) The protective effect of 2-chloroadenosine against the development of amygdala kindling and on amygdala-kindled seizures. Eur.J.Pharmacol. 326 7 PMID: 9178649
If you know of a relevant reference for 2-Chloroadenosine, please let us know.
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Keywords: 2-Chloroadenosine, supplier, adenosines, receptors, agonists, Non-Selective, 2CADO, 2-CADO, Non-selective, Adenosine, Non-selective, Adenosine, Tocris Bioscience
1 Citation for 2-Chloroadenosine
Citations are publications that use Tocris products. Selected citations for 2-Chloroadenosine include:
Nowak et al (2010) The A2aR adenosine receptor controls cytokine production in iNKT cells. Front Cell Neurosci 40 682 PMID: 20039304
Do you know of a great paper that uses 2-Chloroadenosine from Tocris? If so please let us know.
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