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Discontinued Product2,4-Dihydroxyphenylacetyl-L-asparagine (Cat. No. 0262) has been withdrawn from sale for commercial reasons.
Constituent of various spider toxins. Reported to be specific blocker of glutamate receptors.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Pan-Hou et al (1987) Inhibitory effect of 2,4-dihydroxyphenylacetylasparagine, a common moiety of spider toxin, on glutamate binding to rat brain synaptic membranes. Neurosci.Lett. 81 199 PMID: 2827066
Pan-Hou et al (1989) A spider toxin (JSTX) inhibits L-glutamate uptake by rat brain synaptosomes. Brain Res. 476 354 PMID: 2564797
Usherwood et al (1990) Mechanisms of neurotoxicity of low molecular weight spider toxins. Basic Science in Toxicology. Ed. G.N. Volans 569
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Keywords: 2,4-Dihydroxyphenylacetyl-L-asparagine, 2,4-Dihydroxyphenylacetyl-L-asparagine supplier, Component, Joro, spider, toxin, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, antagonists, blockers, Miscellaneous, 0262, Tocris Bioscience
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Learning & Memory Poster
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