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Submit Review2,4-Dihydroxyphenylacetyl-L-asparagine
Description: Component of Joro spider toxin
Biological Activity for 2,4-Dihydroxyphenylacetyl-L-asparagine
Constituent of various spider toxins. Reported to be specific blocker of glutamate receptors.
Technical Data for 2,4-Dihydroxyphenylacetyl-L-asparagine
| M. Wt | 282.25 |
| Formula | C12H14N2O6 |
| Storage | Desiccate at -20°C |
| CAS Number | 111872-98-1 |
| PubChem ID | 3082629 |
| InChI Key | XWUFTPIDMLSXES-QMMMGPOBSA-N |
| Smiles | OC1=CC=C(CC(N[C@@]([H])(CC(N)=O)C(O)=O)=O)C(O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 2,4-Dihydroxyphenylacetyl-L-asparagine
References for 2,4-Dihydroxyphenylacetyl-L-asparagine
References are publications that support the biological activity of the product.
Pan-Hou et al (1987) Inhibitory effect of 2,4-dihydroxyphenylacetylasparagine, a common moiety of spider toxin, on glutamate binding to rat brain synaptic membranes. Neurosci.Lett. 81 199 PMID: 2827066
Pan-Hou et al (1989) A spider toxin (JSTX) inhibits L-glutamate uptake by rat brain synaptosomes. Brain Res. 476 354 PMID: 2564797
Usherwood et al (1990) Mechanisms of neurotoxicity of low molecular weight spider toxins. Basic Science in Toxicology. Ed. G.N. Volans 569
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Keywords: 2,4-Dihydroxyphenylacetyl-L-asparagine, 2,4-Dihydroxyphenylacetyl-L-asparagine supplier, Component, Joro, spider, toxin, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, antagonists, blockers, Miscellaneous, 0262, Tocris Bioscience
Citations for 2,4-Dihydroxyphenylacetyl-L-asparagine
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.