You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
GTP cyclohydrolase I (GCH1) inhibitor. Prevents the de novo synthesis of tetrahydrobiopterin (BH4) and thus suppresses the activity of NO synthase. Exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein).
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in DMSO|
References are publications that support the biological activity of the product.
Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPs 18 204 PMID: 9226999
Werner-Felmayer et al (1993) Pteridine biosynthesis in human endothelial cells. Impact of NO-mediated formation of cyclic GMP. J.Biol.Chem. 268 1842 PMID: 7678411
Xie et al (1998) GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine. J.Biol.Chem. 273 21091 PMID: 9694862
Charles et al (2019) Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescence. Eur.J.Pharmacol. 848 1 PMID: 30690003
If you know of a relevant reference for 2,4-Diamino-6-hydroxypyrimidine, please let us know.
View Related Products by Product Action
Keywords: 2,4-Diamino-6-hydroxypyrimidine, 2,4-Diamino-6-hydroxypyrimidine supplier, GTP, cyclohydrolase, I, inhibitor, GCH1, GTPCH, GCH, inhibitors, inhibits, biosynthesis, tetrahydrobiopterin, BH4, NOS, Nitric, Oxide, synthase, Signaling, Signalling, Other, Hydrolases, 0476, Tocris Bioscience
Citations for 2,4-Diamino-6-hydroxypyrimidine
Citations are publications that use Tocris products.
Currently there are no citations for 2,4-Diamino-6-hydroxypyrimidine. Do you know of a great paper that uses 2,4-Diamino-6-hydroxypyrimidine from Tocris? Please let us know.
Reviews for 2,4-Diamino-6-hydroxypyrimidine
There are currently no reviews for this product. Be the first to review 2,4-Diamino-6-hydroxypyrimidine and earn rewards!
Have you used 2,4-Diamino-6-hydroxypyrimidine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.