2,4-Diamino-6-hydroxypyrimidine

Pricing Availability   Qty
Cat.No. 0476 - 2,4-Diamino-6-hydroxypyrimidine | C4H6N4O | CAS No. 56-06-4
Description: Inhibits tetrahydrobiopterin synthesis and thus NOS activity
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

GTP cyclohydrolase I (GCH1) inhibitor. Prevents the de novo synthesis of tetrahydrobiopterin (BH4) and thus suppresses the activity of NO synthase. Exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein).

Technical Data

M. Wt 126.12
Formula C4H6N4O
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 56-06-4
PubChem ID 2944
InChI Key SWELIMKTDYHAOY-UHFFFAOYSA-N
Smiles NC1=NC(N)=NC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble in DMSO

References

References are publications that support the biological activity of the product.

Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPs 18 204 PMID: 9226999

Werner-Felmayer et al (1993) Pteridine biosynthesis in human endothelial cells. Impact of NO-mediated formation of cyclic GMP. J.Biol.Chem. 268 1842 PMID: 7678411

Xie et al (1998) GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine. J.Biol.Chem. 273 21091 PMID: 9694862

Charles et al (2019) Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescence. Eur.J.Pharmacol. 848 1 PMID: 30690003


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Keywords: 2,4-Diamino-6-hydroxypyrimidine, 2,4-Diamino-6-hydroxypyrimidine supplier, GTP, cyclohydrolase, I, inhibitor, GCH1, GTPCH, GCH, inhibitors, inhibits, biosynthesis, tetrahydrobiopterin, BH4, NOS, Nitric, Oxide, synthase, Signaling, Signalling, Other, Hydrolases, 0476, Tocris Bioscience

Citations for 2,4-Diamino-6-hydroxypyrimidine

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