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Description: Negative control for 1S,3R-RSL3 (Cat. No. 6118)
Chemical Name: (1R,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
Purity: ≥98% (HPLC)

Biological Activity for 1R,3R-RSL3

1R,3R-RSL3 is a negative control for 1S,3R-RSL3 (Cat. No. 6118).

Licensing Information

Sold with the permission of Columbia University.

Technical Data for 1R,3R-RSL3

M. Wt 440.88
Formula C23H21ClN2O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1219810-15-7
PubChem ID 1750827
Smiles COC([C@H]1CC2=C([C@@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=CC=CC=C24)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 1R,3R-RSL3

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 44.09 100

Preparing Stock Solutions for 1R,3R-RSL3

The following data is based on the product molecular weight 440.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References for 1R,3R-RSL3

References are publications that support the biological activity of the product.

Yang et al (2016) Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc.Natl.Acad.Sci.U.S.A. 113 E4966 PMID: 27506793

If you know of a relevant reference for 1R,3R-RSL3, please let us know.

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Citations for 1R,3R-RSL3

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