Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization.
(Modifications: Phe-2 = D-Phe, Pro-3 = D-Pro, Phe-4 = D-Phe, Pro-6 = D-Pro, Cyclized)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1784.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.56 mL||2.8 mL||5.6 mL|
|5 mM||0.11 mL||0.56 mL||1.12 mL|
|10 mM||0.06 mL||0.28 mL||0.56 mL|
|50 mM||0.01 mL||0.06 mL||0.11 mL|
References are publications that support the products' biological activity.
Suetsugu et al (2001) Identification of another actin-related (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J.Biol.Chem. 276 33175 PMID: 11432863
Prehoda and Lim (2002) How signaling proteins integrate multiple inputs: a comparison of N-WASP and cdk2. Curr.Opin.Cell Biol. 14 149 PMID: 11891112
If you know of a relevant reference for 187-1, N-WASP inhibitor, please let us know.
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Keywords: 187-1, N-WASP inhibitor, supplier, inhibitors, inhibits, actin, assembly, neural, Wiskott-Aldrich, syndrome, protein, Actin, Actin, Tocris Bioscience
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