187-1, N-WASP inhibitor

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Cat.No. 2067 - 187-1, N-WASP inhibitor | cyclo(Lys-D-Phe-D-Pro-D-Phe-Phe-D-Pro-Gln)2 | CAS No. 380488-27-7
Description: N-WASP inhibitor; inhibits actin assembly
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Biological Activity

Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization.

Technical Data

M. Wt 1784.13
Formula C96H122N18O16
Sequence KFPFFPQ KFPFFPQ

(Modifications: Phe-2 = D-Phe, Pro-3 = D-Pro, Phe-4 = D-Phe, Pro-6 = D-Pro, Cyclized)

Storage Desiccate at -20°C
CAS Number 380488-27-7
PubChem ID 44405676
InChI Key PHTIQAVQWWOKNF-RNEDXEELSA-N
Smiles NCCCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CC2=CC=CC=C2)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1784.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.56 mL 2.8 mL 5.6 mL
5 mM 0.11 mL 0.56 mL 1.12 mL
10 mM 0.06 mL 0.28 mL 0.56 mL
50 mM 0.01 mL 0.06 mL 0.11 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Suetsugu et al (2001) Identification of another actin-related (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J.Biol.Chem. 276 33175 PMID: 11432863

Prehoda and Lim (2002) How signaling proteins integrate multiple inputs: a comparison of N-WASP and cdk2. Curr.Opin.Cell Biol. 14 149 PMID: 11891112

Peterson et al (2001) A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc.Natl.Acad.Sci.USA 98 10624 PMID:


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