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Submit Review15-deoxy-Δ-12,14-Prostaglandin J2
Description: Endogenous PPARγ agonist
Chemical Name: (5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid
Purity: ≥95% (HPLC)
Biological Activity for 15-deoxy-Δ-12,14-Prostaglandin J2
15-deoxy-Δ-12,14-Prostaglandin J2 is a selective PPARγ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7 μM).
Technical Data for 15-deoxy-Δ-12,14-Prostaglandin J2
| M. Wt | 316.44 |
| Formula | C20H28O3 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 87893-55-8 |
| PubChem ID | 5311211 |
| InChI Key | VHRUMKCAEVRUBK-GODQJPCRSA-N |
| Smiles | O=C/1C=C[C@@H](C1=C/C=C/CCCCC)C/C=C\CCCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 15-deoxy-Δ-12,14-Prostaglandin J2
References for 15-deoxy-Δ-12,14-Prostaglandin J2
References are publications that support the biological activity of the product.
Forman et al (1995) 15-Deoxy-Δ12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83 803 PMID: 8521497
Kliewer et al (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83 813 PMID: 8521498
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Keywords: 15-deoxy-D-12,14-Prostaglandin J2, 15-deoxy-D-12,14-Prostaglandin J2 supplier, Endogenous, PPARγ, PPARgamma, agonists, Peroxisome, Proliferator-activating, Receptors, 15-deoxy-Delta-12, 14-Prostaglandin, J2, 15-deoxy-D-1214-ProstaglandinJ2, 2306, Tocris Bioscience
Citations for 15-deoxy-Δ-12,14-Prostaglandin J2
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Currently there are no citations for 15-deoxy-Δ-12,14-Prostaglandin J2.
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Average Rating: 5 (Based on 1 Review.)
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15d-PGJ2 promotes MAPK activation in cardiomyocytes.
By
Chintan Koyani on 10/13/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Cardiomyocytes
Treatment of HL-1 cells (15 min) with increasing 15d-PGJ2 concentrations induced phosphorylation of p38 and p42/44 MAPK (shown in Image). A As pronounced MAPK activation was observed at 15 μM 15d-PGJ2.
