15-deoxy-Δ-12,14-Prostaglandin J2

Discontinued Product

15-deoxy-Δ-12,14-Prostaglandin J2 (Cat. No. 2306) has been withdrawn from sale for commercial reasons.
Description: Endogenous PPARγ agonist
Chemical Name: (5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid
Purity: ≥95% (HPLC)
Reviews (1)
Literature (1)

Biological Activity for 15-deoxy-Δ-12,14-Prostaglandin J2

15-deoxy-Δ-12,14-Prostaglandin J2 is a selective PPARγ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7 μM).

Technical Data for 15-deoxy-Δ-12,14-Prostaglandin J2

M. Wt 316.44
Formula C20H28O3
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 87893-55-8
PubChem ID 5311211
Smiles O=C/1C=C[C@@H](C1=C/C=C/CCCCC)C/C=C\CCCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for 15-deoxy-Δ-12,14-Prostaglandin J2

Certificate of Analysis / Product Datasheet
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References for 15-deoxy-Δ-12,14-Prostaglandin J2

References are publications that support the biological activity of the product.

Forman et al (1995) 15-Deoxy-Δ12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83 803 PMID: 8521497

Kliewer et al (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83 813 PMID: 8521498

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Keywords: 15-deoxy-D-12,14-Prostaglandin J2, 15-deoxy-D-12,14-Prostaglandin J2 supplier, Endogenous, PPARγ, PPARgamma, agonists, Peroxisome, Proliferator-activating, Receptors, 15-deoxy-Delta-12, 14-Prostaglandin, J2, 15-deoxy-D-1214-ProstaglandinJ2, 2306, Tocris Bioscience

Citations for 15-deoxy-Δ-12,14-Prostaglandin J2

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Currently there are no citations for 15-deoxy-Δ-12,14-Prostaglandin J2.

Reviews for 15-deoxy-Δ-12,14-Prostaglandin J2

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15d-PGJ2 promotes MAPK activation in cardiomyocytes.
By Chintan Koyani on 10/13/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Cardiomyocytes

Treatment of HL-1 cells (15 min) with increasing 15d-PGJ2 concentrations induced phosphorylation of p38 and p42/44 MAPK (shown in Image). A As pronounced MAPK activation was observed at 15 μM 15d-PGJ2.

PMID: 24698234
review image

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