15-deoxy-Δ-12,14-Prostaglandin J2
Biological Activity
Selective PPARγ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7 μM).
Technical Data
| M. Wt | 316.44 |
| Formula | C20H28O3 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 87893-55-8 |
| PubChem ID | 5311211 |
| InChI Key | VHRUMKCAEVRUBK-GODQJPCRSA-N |
| Smiles | O=C/1C=C[C@@H](C1=C/C=C/CCCCC)C/C=C\CCCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in Methyl acetate (supplied pre-dissolved - 1mg/ml) |
Preparing Stock Solutions
The following data is based on the product molecular weight 316.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.16 mL | 15.8 mL | 31.6 mL |
| 5 mM | 0.63 mL | 3.16 mL | 6.32 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.16 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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References
References are publications that support the products' biological activity.
Forman et al (1995) 15-Deoxy-Δ12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83 803 PMID: 8521497
Kliewer et al (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83 813 PMID: 8521498
If you know of a relevant reference for 15-deoxy-Δ-12,14-Prostaglandin J2, please let us know.
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Citations for 15-deoxy-Δ-12,14-Prostaglandin J2
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