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Submit Review15-deoxy-Δ-12,14-Prostaglandin J2
Description: Endogenous PPARγ agonist
Chemical Name: (5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid
Purity: ≥95% (HPLC)
Biological Activity
Selective PPARγ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7 μM).
Technical Data
| M. Wt | 316.44 |
| Formula | C20H28O3 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 87893-55-8 |
| PubChem ID | 5311211 |
| InChI Key | VHRUMKCAEVRUBK-GODQJPCRSA-N |
| Smiles | O=C/1C=C[C@@H](C1=C/C=C/CCCCC)C/C=C\CCCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble in Methyl acetate (supplied pre-dissolved - 1mg/ml) |
Product Datasheets
References
References are publications that support the biological activity of the product.
Forman et al (1995) 15-Deoxy-Δ12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83 803 PMID: 8521497
Kliewer et al (1995) A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83 813 PMID: 8521498
If you know of a relevant reference for 15-deoxy-Δ-12,14-Prostaglandin J2, please let us know.
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15d-PGJ2 promotes MAPK activation in cardiomyocytes.
By
Chintan Koyani on 10/13/2018
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: Cardiomyocytes
Treatment of HL-1 cells (15 min) with increasing 15d-PGJ2 concentrations induced phosphorylation of p38 and p42/44 MAPK (shown in Image). A As pronounced MAPK activation was observed at 15 μM 15d-PGJ2.
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