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Pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα respectively.) Inhibits NF-κB activation and blocks IL-8 production in U937 cells (IC50 values are 1-2 and 0.34-0.48 μM respectively).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 324.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||30.85 mL||154.26 mL||308.52 mL|
|0.5 mM||6.17 mL||30.85 mL||61.7 mL|
|1 mM||3.09 mL||15.43 mL||30.85 mL|
|5 mM||0.62 mL||3.09 mL||6.17 mL|
References are publications that support the biological activity of the product.
Tasdemir et al (2002) Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J.Med.Chem. 45 529 PMID: 11784156
Meijer et al (2000) Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent. Chem.Biol. 7 51 PMID: 10662688
Breton and Chabot-Fletcher (1997) The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-κB. J.Pharmacol.Exp.Ther. 282 459 PMID: 9223588
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
If you know of a relevant reference for 10Z-Hymenialdisine, please let us know.
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Keywords: 10Z-Hymenialdisine, 10Z-Hymenialdisine supplier, SK&F108752, potent, pan, kinase, inhibitors, inhibits, CK1, Cdk, GSK-3beta, GSK-3b, cyclin, Erk1, MEK-1, MEK1, PKC, NF-kB, NF-kappaB, activation, IL-8, production, anti-inflammatory, SK&F, 108752, Broad, Spectrum, Protein, Kinase, Inhibitors, 1532, Tocris Bioscience
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