Pan kinase inhibitor (IC50 values are 6, 10, 22, 28, 35, 40, 70, 80, 100, 470, 500, 600, 700 and 700 nM for MEK1, GSK-3β, Cdk1/cyclin B, Cdk5/p25, CK1, Cdk2/cyclin A, Cdk2/cyclin E, ASK-γ, Cdk3/cyclin E, Erk1, PKCγ, Cdk4/cyclin D1, Cdk6/cyclin D2 and PKCα respectively.) Inhibits NF-κB activation and blocks IL-8 production in U937 cells (IC50 values are 1-2 and 0.34-0.48 μM respectively).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 324.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.09 mL||15.43 mL||30.85 mL|
|5 mM||0.62 mL||3.09 mL||6.17 mL|
|10 mM||0.31 mL||1.54 mL||3.09 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References are publications that support the products' biological activity.
Tasdemir et al (2002) Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J.Med.Chem. 45 529 PMID: 11784156
Meijer et al (2000) Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent. Chem.Biol. 7 51 PMID: 10662688
Breton and Chabot-Fletcher (1997) The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor-κB. J.Pharmacol.Exp.Ther. 282 459 PMID: 9223588
If you know of a relevant reference for 10Z-Hymenialdisine, please let us know.
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Keywords: 10Z-Hymenialdisine, supplier, SK&F108752, potent, pan, kinase, inhibitors, inhibits, CK1, Cdk, GSK-3beta, GSK-3b, cyclin, Erk1, MEK-1, MEK1, PKC, NF-kB, NF-kappaB, activation, IL-8, production, anti-inflammatory, SK&F, 108752, MEK, Glycogen, Synthase, Kinase, 3, Glycogen, Synthase, Kinase, Cyclin-dependent, Kinase, NF-kB/IkB, Cytokines, MEK, Tocris Bioscience
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Literature in this Area
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.