1-Deoxymannojirimycin hydrochloride

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Cat.No. 1259 - 1-Deoxymannojirimycin hydrochloride | C6H13NO4.HCl | CAS No. 73465-43-7
Description: α-Mannosidase I inhibitor
Chemical Name: (2R,3R,4R,5R)-2-(Hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
Datasheet
Citations (1)
Reviews

Biological Activity for 1-Deoxymannojirimycin hydrochloride

1-Deoxymannojirimycin hydrochloride is a selective inhibitor of α-mannosidase I.

Technical Data for 1-Deoxymannojirimycin hydrochloride

M. Wt 199.63
Formula C6H13NO4.HCl
Storage Desiccate at RT
CAS Number 73465-43-7
PubChem ID 11019872
InChI Key ZJIHMALTJRDNQI-MVNLRXSJSA-N
Smiles Cl[H].OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 1-Deoxymannojirimycin hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.98 50

Preparing Stock Solutions for 1-Deoxymannojirimycin hydrochloride

The following data is based on the product molecular weight 199.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 10.02 mL 50.09 mL 100.19 mL
2.5 mM 2 mL 10.02 mL 20.04 mL
5 mM 1 mL 5.01 mL 10.02 mL
25 mM 0.2 mL 1 mL 2 mL

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Product Datasheets for 1-Deoxymannojirimycin hydrochloride

Certificate of Analysis / Product Datasheet
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References for 1-Deoxymannojirimycin hydrochloride

References are publications that support the biological activity of the product.

Bischoff et al (1986) The use of 1-deoxymannojirimycin to evaluate the role of various α-mannosidases in oligosaccharide processing in intact cells. J.Biol.Chem. 261 4766 PMID: 2937779

Bischoff and Kornfeld (1984) The effect of 1-deoxymannojirimycin on rat liver α-mannosidases. Biochem.Biophys.Res.Commun. 125 324 PMID: 6239623

Fuhrmann et al (1984) Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides. Nature 307 755 PMID: 6230538


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Keywords: 1-Deoxymannojirimycin hydrochloride, 1-Deoxymannojirimycin hydrochloride supplier, α-mannosidase, alpha-mannosidase, I, inhibitors, inhibits, a-Mannosidase, Glycosylases, Carbohydrate, Metabolism, antibiotics, Antibiotics, 1259, Tocris Bioscience

1 Citation for 1-Deoxymannojirimycin hydrochloride

Citations are publications that use Tocris products. Selected citations for 1-Deoxymannojirimycin hydrochloride include:

Tareen et al (2014) Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells. Mol Ther 22 575 PMID: 24419083


Do you know of a great paper that uses 1-Deoxymannojirimycin hydrochloride from Tocris? Please let us know.

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