1-Deoxymannojirimycin hydrochloride

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Cat.No. 1259 - 1-Deoxymannojirimycin hydrochloride | C6H13NO4.HCl | CAS No. 73465-43-7
Description: α-Mannosidase I inhibitor
Chemical Name: (2R,3R,4R,5R)-2-(Hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective inhibitor of α-mannosidase I.

Technical Data

M. Wt 199.63
Formula C6H13NO4.HCl
Storage Desiccate at RT
CAS Number 73465-43-7
PubChem ID 11019872
InChI Key ZJIHMALTJRDNQI-MVNLRXSJSA-N
Smiles Cl[H].OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.98 50

Preparing Stock Solutions

The following data is based on the product molecular weight 199.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 10.02 mL 50.09 mL 100.19 mL
2.5 mM 2 mL 10.02 mL 20.04 mL
5 mM 1 mL 5.01 mL 10.02 mL
25 mM 0.2 mL 1 mL 2 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Bischoff et al (1986) The use of 1-deoxymannojirimycin to evaluate the role of various α-mannosidases in oligosaccharide processing in intact cells. J.Biol.Chem. 261 4766 PMID: 2937779

Bischoff and Kornfeld (1984) The effect of 1-deoxymannojirimycin on rat liver α-mannosidases. Biochem.Biophys.Res.Commun. 125 324 PMID: 6239623

Fuhrmann et al (1984) Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides. Nature 307 755 PMID: 6230538


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Keywords: 1-Deoxymannojirimycin hydrochloride, 1-Deoxymannojirimycin hydrochloride supplier, α-mannosidase, alpha-mannosidase, I, inhibitors, inhibits, a-Mannosidase, Glycosylases, Carbohydrate, Metabolism, antibiotics, Antibiotics, 1259, Tocris Bioscience

1 Citation for 1-Deoxymannojirimycin hydrochloride

Citations are publications that use Tocris products. Selected citations for 1-Deoxymannojirimycin hydrochloride include:

Tareen et al (2014) Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells. Mol Ther 22 575 PMID: 24419083


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Literature in this Area

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