1-(4-Bromobenzoyl)piperazine-2,3-dicarboxylic acid sodium salt
Discontinued ProductUnfortunately 1-(4-Bromobenzoyl)piperazine-2,3-dicarboxylic acid sodium salt (Cat. No. 0167) has been withdrawn from sale for commercial reasons.
Antagonist at non-NMDA receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 379.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.64 mL||13.19 mL||26.38 mL|
|5 mM||0.53 mL||2.64 mL||5.28 mL|
|10 mM||0.26 mL||1.32 mL||2.64 mL|
|50 mM||0.05 mL||0.26 mL||0.53 mL|
References are publications that support the products' biological activity.
Davies et al (1984) Phosphonodipeptides and piperazine derivatives as antagonists of amino acid-induced and synaptic excitation in mammalian and amphibian spinal cord. Neurosci.Lett. 52 79 PMID: 6098881
Evans et al (1987) A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat. Br.J.Pharmacol. 91 531 PMID: 3038242
Watkins et al (1990) Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of non-NMDA receptors. Excitatory amino acids and neuronal plasticity. Ed 49 PMID:
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Keywords: 1-(4-Bromobenzoyl)piperazine-2,3-dicarboxylic acid sodium salt, supplier, Non-selective, Ionotropic, Glutamate, Non-selective, Ionotropic, Glutamate, Tocris Bioscience
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.