- Cell Biology
- Product Type
- Research Area
- New Products
- About Tocris
- Contact Us
Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C′-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.
We are sorry, but we currently do not have any Diacylglycerol Kinase products at this time. Please feel free to send us your requirements via our New Product Suggestions form.
Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKα, DGKβ, DGKγ, DGKδ, DGKε, DGKζ, DGKη, DGKθ, DGKι and DGKκ) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C′-terminal catalytic domain, two cysteine-rich Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies.
DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKα), some are membrane-bound (for example DGKγ is associated with the Golgi membrane) and some are nuclear (for example DGKζ). DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.
Tocris offers the following scientific literature for Diacylglycerol Kinases to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|