Diacylglycerol Kinases

Diacylglycerol kinases (DGKs) are a group of ten enzymes that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C′-terminal catalytic domain and two cysteine-rich Zn2+-finger motifs with varied regulatory domains.

Literature (1)
Gene Data

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Diacylglycerol kinases (DGKs) are a group of ten enzymes (DGKα, DGKβ, DGKγ, DGKδ, DGKε, DGKζ, DGKη, DGKθ, DGKι and DGKκ) that metabolize 1,2,diacylglycerol (DAG) to produce phosphatidic acid (PA). They all contain a conserved C′-terminal catalytic domain, two cysteine-rich Zn2+-finger motifs that bind DAG and an ATP-binding site, whilst the regulatory domain varies.

DGKs are widely distributed throughout mammalian tissues and different isozymes have different subcellular localizations; some are cytosolic (for example DGKα), some are membrane-bound (for example DGKγ is associated with the Golgi membrane) and some are nuclear (for example DGKζ). DGKs have diverse biological roles as they participate in signal transduction by modulating levels of DAG in a variety of cellular responses to extracellular stimuli.

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    Literature for Diacylglycerol Kinases

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    Diacylglycerol Kinase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    DGKα Human DGKA NM_201554 P23743
    Mouse Dgka NM_016811 O88673
    Rat Dgka NM_080787 P51556
    DGKβ Human DGKB NM_004080 Q9UQ29
    Mouse Dgkb NM_178681 Q6NS52
    Rat Dgkb NM_019304 P49621
    DGKγ Human DGKG NM_001080744 P49619
    Mouse Dgkg NM_138650 Q91WG7
    Rat Dgkg NM_013126 P49620
    DGKδ Human DGKD NM_003648 Q16760
    Mouse Dgkd AK172901 Q6A0B7
    Rat Dgkd XM_343621 -
    DGKε Human DGKE NM_003647 P52429
    Mouse Dgke NM_019505 Q9R1C6
    DGKζ Human DGKZ NM_001105540 Q13574
    Mouse Dgkz NM_138306 Q80UP3
    Rat Dgkz NM_031143 O08560
    DGKη Human DGKH NM_178009 Q86XP1
    Mouse Dgkh NM_001081336 NP_001074805
    DGKθ Human DGKQ NM_001347 P52824
    Mouse Dgkq NM_199011 NP_950176
    DGKι Human DGKI NM_004717 O75912
    Mouse Dgki NM_001081206 NP_001074675
    Rat Dgki NM_198782 Q810C3
    DGKκ Human DGKK NM_001013742 Q5KSL6
    Mouse Dgkk NM_177914 NP_808582
    Rat Dgkk XM_346276 XP_346277