WKYMVm

Cat. No. 1800

WKYMVm Trp-Lys-Tyr-Met-Val-D-Met-NH2

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Alternative Name: Leukocyte chemoattractant peptide

Biological Activity

Selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM), expressed on immune cells. Induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway.

Technical Data

M.Wt:
856.11
Formula:
C41H61N9O7S2
Sequence:
WKYMVM

(Modifications: Met-6 = D-Met & C-terminal amide)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
187986-17-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Bae et al (2002) The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation. J.Leukoc.Biol. 71 329. PMID: 11818455.

Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585. PMID: 11285256.

Le et al (1999) Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and fomyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J.Immunol. 163 6777. PMID: 10586077.

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Citations are publications that use Tocris products. Selected citations for WKYMVm include:

Thompson et al (2014) Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: ASSOCIATION WITH CELL PROTECTION FROM APOPTOSIS. J Biol Chem 289 36166. PMID: 25326384.

Khau et al (2011) Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. Invest Ophthalmol Vis Sci 25 483. PMID: 20930115.

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Keywords: WKYMVm, supplier, FPR1, FPR2, FPR3, receptor, agonists, FPRL, Formyl, like, Peptide, Receptors, Tocris Bioscience, Formyl Peptide Receptor Agonist products

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