Veratridine

Cat. No. 2918

Veratridine C36H51NO11 [71-62-5]

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Chemical Name: 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol

Biological Activity

Voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.

Technical Data

M.Wt:
673.79
Formula:
C36H51NO11
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
71-62-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Fekete et al (2009) Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy. J.Neurochem. 111 745. PMID: 19719824.

Maroto et al (1994) Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine. Eur.J.Pharmacol. 270 331. PMID: 7805782.

McKinney et al (1986) Purification, solubility and pKa of veratridine. Anal.Biochem. 153 33. PMID: 3963380.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Veratridine include:

Battefeld et al (2016) Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Biol Psychiatry 7 11298. PMID: 27161034.

Malmersjö et al (2013) Neural progenitors organize in small-world networks to promote cell proliferation. Nat Commun 110 E1524. PMID: 23576737.

Do you know of a great paper that uses Veratridine from Tocris? If so please let us know.

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Keywords: Veratridine, supplier, Sodium, channel, opener, neutoxin, Na+, Na, voltage-gated, ion, channels, neurotoxins, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Activator products

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