Cat. No. 2672
Alternative Name: TA 0910
Chemical Name: N-[[(4S)-Hexahydro-1-methyl-2,6-dio
Biological ActivitySynthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Tanabe et al (2007) The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems. Br.J.Pharmacol. 150 403. PMID: 17220907.
Urayama et al (2002) Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sci. 72 601. PMID: 12467901.
Suzuki et al (1990) Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety. J.Med.Chem. 33 2130. PMID: 2115588.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Taltirelin include:
Thirunarayanan et al (2012) Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor. PeerJ 3 120. PMID: 23087672.
Do you know of a great paper that uses Taltirelin from Tocris? If so please let us know.
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Keywords: Taltirelin, supplier, Synthetic, thyrotropin-releasing, hormone, TRH, Receptors, TA0910, Tocris Bioscience, Thyrotropin-Releasing Hormone Receptor Agonist products
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