Taltirelin

Cat. No. 2672

Taltirelin C17H23N7O5 [103300-74-9]

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Alternative Name: TA 0910

Chemical Name: N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide

Biological Activity

Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.

Technical Data

M.Wt:
405.41
Formula:
C17H23N7O5
Solubility:
Soluble to 50 mM in water
Purity:
>96 %
Storage:
Store at -20°C
CAS No:
103300-74-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Tanabe et al (2007) The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems. Br.J.Pharmacol. 150 403. PMID: 17220907.

Urayama et al (2002) Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sci. 72 601. PMID: 12467901.

Suzuki et al (1990) Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety. J.Med.Chem. 33 2130. PMID: 2115588.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Taltirelin include:

Thirunarayanan et al (2012) Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor. PeerJ 3 120. PMID: 23087672.

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Keywords: Taltirelin, supplier, Synthetic, thyrotropin-releasing, hormone, TRH, Receptors, TA0910, Tocris Bioscience, Thyrotropin-Releasing Hormone Receptor Agonist products

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