Taltirelin

Cat. No. 2672

Taltirelin C17H23N7O5 [103300-74-9]

Price and Availability

For Taltirelin pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: TA 0910

Chemical Name: N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide

Biological Activity

Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.

Technical Data

M.Wt:
405.41
Formula:
C17H23N7O5
Solubility:
Soluble to 50 mM in water
Purity:
>96 %
Storage:
Store at -20°C
CAS No:
103300-74-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Tanabe et al (2007) The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems. Br.J.Pharmacol. 150 403. PMID: 17220907.

Urayama et al (2002) Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sci. 72 601. PMID: 12467901.

Suzuki et al (1990) Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety. J.Med.Chem. 33 2130. PMID: 2115588.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Taltirelin include:

Thirunarayanan et al (2012) Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor. PeerJ 3 120. PMID: 23087672.

Do you know of a great paper that uses Taltirelin from Tocris? If so please let us know.

View Related Products by Target

Keywords: Taltirelin, supplier, Synthetic, thyrotropin-releasing, hormone, TRH, Receptors, TA0910, Tocris Bioscience, Thyrotropin-Releasing Hormone Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

New Products in this Area

Spexin

Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo

MM 54

Potent apelin receptor antagonist

MSG 606

Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.