Cat. No. 5868
Chemical Name: 2-Chloro-N-[4-[2,2,2-trifluoro-1-hy
Biological ActivityT cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Chang et al (2016) Synthetic RORγt agonists enhance protective immunity. ACS Chem.Biol. 11 1012. PMID: 26785144 .
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Keywords: SR 0987, supplier, SR0987, T-cell, specific, RORgamma, RORg, RORγ, agonists, agonism, cancer, immunity, antitumor, immunotherapy, immunology, Tocris Bioscience, Retinoic Acid-related Orphan Receptor Agonist products
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