Cat. No. 5868
Chemical Name: 2-Chloro-N-[4-[2,2,2-trifluoro-1-hy
Biological ActivityT cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chang et al (2016) Synthetic RORγt agonists enhance protective immunity. ACS Chem.Biol. 11 1012. PMID: 26785144 .
If you know of a relevant reference for SR 0987 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SR 0987 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SR 0987, supplier, SR0987, T-cell, specific, RORgamma, RORg, RORγ, agonists, agonism, cancer, immunity, antitumor, immunotherapy, immunology, Tocris Bioscience, Retinoic Acid-related Orphan Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Synthetic progesterone analogC-DIM 12
Nurr1 activator; inhibits NF-κB-dependent gene expression(S)-Equol
Potent estrogen receptor β (ERβ) agonistAilanthone
Potent inhibitor of androgen receptor (AR)(±)-ML 209
RORγt inverse agonist; suppresses Th17 cell differentiationAGN 193109
High affinity pan-RAR antagonistSR 9243
Selective LXR inverse agonist
August 20 - 24, 2017
Paris , France