Cat. No. 5868
Chemical Name: 2-Chloro-N-[4-[2,2,2-trifluoro-1-hy
Biological ActivityT cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Chang et al (2016) Synthetic RORγt agonists enhance protective immunity. ACS Chem.Biol. 11 1012. PMID: 26785144 .
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Keywords: SR 0987, supplier, SR0987, T-cell, specific, RORgamma, RORg, RORγ, agonists, agonism, cancer, immunity, antitumor, immunotherapy, immunology, Tocris Bioscience, Retinoic Acid-related Orphan Receptor Agonist products
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