SR 0987

Cat. No. 5868new

SR 0987 C16H10ClF6NO2 [303126-97-8]

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Chemical Name: 2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide

Biological Activity

T cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Chang et al (2016) Synthetic RORγt agonists enhance protective immunity. ACS Chem.Biol. 11 1012. PMID: 26785144 .

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Keywords: SR 0987, supplier, SR0987, T-cell, specific, RORgamma, RORg, RORγ, agonists, agonism, cancer, immunity, antitumor, immunotherapy, immunology, Tocris Bioscience, Retinoic Acid-related Orphan Receptor Agonist products

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