GSK 591 dihydrochloride
Cat. No. 5777
Alternative Names: EPZ015866, GSK 3203591
Chemical Name: 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-
Biological ActivityPotent and selective PRMT5 inhibitor (IC50 = 4 nM). Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro.
Licensing InformationThis probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK591 probe summary on the SGC website.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK591 is reviewed on the Chemical Probes website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Duncan et al (2015) Structure and property guided design in the identification of PRMT5 tool compound EPZ015666. ACS.Med.Chem.Lett. 7 162. PMID: 26985292.
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Keywords: GSK 591 dihydrochloride, supplier, GSK591, dihydrochloride, protein, arginine, methyltransferases, inhibitors, inhibits, potent, selective, PRMT5, 1616391-87-7, Structural, Genomics, Consortium, SGC, GSK3203591, Tocris Bioscience, Protein Arginine Methyltransferase Inhibitor products
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Tocris has a collaboration with the Structural Genomics Consortium (SGC) to provide the latest high quality epigenetics probes.