Cat. No. 5666
Chemical Name: 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenyl
Biological ActivityPotent and selective GPR139 agonist (EC50 = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Dvorak et al (2015) Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor. ACS Med.Chem.Lett. 6 1015. PMID: 26396690.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses JNJ 63533054 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: JNJ 63533054, supplier, JNJ63533054, GPR139, agonists, agonism, potent, selective, orally, available, brain, penetrant, orphan, 7-TM, receptors, Tocris Bioscience, Orphan 7-TM Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonistUMB 68
GHB receptor ligandAZD 1283
High affinity P2Y12 antagonistEx 26
Potent and selective S1P1 receptor antagonistZQ 16
Selective GPR84 agonistIHR-Cy3
Potent fluorescent Smo antagonistRo 6842262
Potent LPA1 antagonistAMG 853
Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonistAM 4668
Potent FFA1 (GPR40) agonistCATPB
FFA2 antagonist/inverse agonistOleanolic acid
Selective GPBA receptor (TGR5) partial agonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.