Roxindole hydrochloride

Cat. No. 1559

Roxindole hydrochloride C23H26N2O.HCl [108050-82-4]

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Alternative Name: EMD 49980

Chemical Name: 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride

Biological Activity

Dopamine D2 autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo.

Technical Data

Soluble to 50 mM in DMSO with gentle warming
>98 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Newman-Tancredi et al (1999) Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Naunyn Schmiedebergs Arch.Pharmacol. 359 447. PMID: 10431754.

Bartoszyk et al (1996) Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J.Pharmacol.Exp.Ther. 276 41. PMID: 8558454.

Seyfried et al (1989) Biochemical and functional studies on EMD 49980: a potent, selectively presynaptic D-2 dopamine agonist with actions on serotonin systems. Eur.J.Pharmacol. 160 31. PMID: 2565817.

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Keywords: Roxindole hydrochloride, supplier, 5-HT, reuptake, inhibitors, inhibits, affinity, 5-HT1A, receptors, D2, dopamine, dopaminergic, agonists, autoreceptor, D3, D4, transporters, Serotonin, 5-HT-, 5-Hydroxytryptamine, Receptors, D2-like, Non-Selective, EMD49980, Tocris Bioscience, Non-selective Dopamine Agonist products

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