BGC 20-1531 hydrochloride

Cat. No. 5327

BGC 20-1531 hydrochloride C26H24N2O6S.HCl

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Alternative Name: PGN 1531

Chemical Name: 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride

Biological Activity

High affinity and selective EP4 antagonist (Ki = 3 nM). Exhibits >2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable.

Technical Data

M.Wt:
529
Formula:
C26H24N2O6S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sutton et al (2014) From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor. Bioorg.Med.Chem.Lett. 24 2212. PMID: 24703233.

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Keywords: BGC 20-1531 hydrochloride, supplier, BGC20-1531, hydrochloride, PGN1531, high, affinity, selective, EP4, antagonists, orally, bioavailable, active, Tocris Bioscience, Prostanoid Receptor Antagonist products

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