ACT 462206

Cat. No. 5319

ACT 462206 C20H24N2O4S [1361321-96-1]

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Chemical Name: (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide

Biological Activity

Potent, dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively). Exhibits anxiolytic-like properties in vivo. Brain penetrant.

Technical Data

M.Wt:
388.48
Formula:
C20H24N2O4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1361321-96-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Boss et al (2014) Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 9 2486. PMID: 25147058.

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Keywords: ACT 462206, supplier, ACT462206, Potent, dual, orexin, receptors, antagonists, OX1, OX2, DORA, anxiolytic, Tocris Bioscience, Non-selective Orexin Antagonist products

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