Cat. No. 5319
Chemical Name: (2S)-N-(3,5-Dimethylphenyl)-1-[(4-m
Biological ActivityPotent, dual orexin receptor antagonist (IC50 values are 11 and 60 nM for OX2 and OX1 receptors respectively). Exhibits anxiolytic-like properties in vivo. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Boss et al (2014) Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist. ChemMedChem. 9 2486. PMID: 25147058.
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Keywords: ACT 462206, supplier, ACT462206, Potent, dual, orexin, receptors, antagonists, OX1, OX2, DORA, anxiolytic, Tocris Bioscience, Non-selective Orexin Antagonist products