Cat. No. 5283
Chemical Name: 7-[(4-Ethoxy-3-methylphenyl)(2-pyri
Biological ActivityE2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Conklin et al (2012) The RB family is required for the self-renewal and survival of human embryonic stem cells. Nat.Commun. 3 1244. PMID: 23212373.
Ma et al (2008) A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Res. 68 6292. PMID: 18676853.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses HLM 006474 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: HLM 006474, supplier, HLM006474, E2F, transcription, factors, inhibits, inhibitors, DNA, binding, A375, melanoma, stems, cells, proliferation, human, embryonic, Tocris Bioscience, Other Transcription Factor products
Find multiple products by catalog number
New Products in this Area
Gene switch ligand for use in induceable gene expression systemsML 334
Inhibitor of Keap1- Nrf2 interactionRA 839
Nrf2 activator; inhibits Nrf2/Keap1 interaction
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.