HLM 006474

Cat. No. 5283

HLM 006474 C25H25N3O2 [353519-63-8]

Price and Availability

For HLM 006474 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol

Biological Activity

E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.

Technical Data

Soluble to 20 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Conklin et al (2012) The RB family is required for the self-renewal and survival of human embryonic stem cells. Nat.Commun. 3 1244. PMID: 23212373.

Ma et al (2008) A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Res. 68 6292. PMID: 18676853.

If you know of a relevant reference for HLM 006474 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses HLM 006474 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: HLM 006474, supplier, HLM006474, E2F, transcription, factors, inhibits, inhibitors, DNA, binding, A375, melanoma, stems, cells, proliferation, human, embryonic, Tocris Bioscience, Other Transcription Factor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area


STAT3 inhibitor; active in vivo

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ISSCR 2017

ISSCR 2017

June 14 - 17, 2017

Boston, MA, USA

Booth: 419