Cat. No. 5025

Necrosulfonamide C18H15N5O6S2 [1360614-48-7]

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Chemical Name: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide

Biological Activity

Necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.

Technical Data

Soluble to 20 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Kreuzaler et al (2012) Killing a cancer: what are the alternatives? Nat.Rev.Cancer. 12 411. PMID: 22576162.

Sun et al (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148 213. PMID: 22265413.

Zhou et al (2012) New components of the necroptotic pathway. Protein Cell 3 811. PMID: 23073834.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Necrosulfonamide include:

Bittner et al (2016) Death receptor 3 mediates necroptotic cell death Cellular and Molecular Life Sciences. PMID: 27592300.

Gonzalez-Juarbe et al (2015) Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. Channels (Austin) 11 e1005337. PMID: 26659062.

Do you know of a great paper that uses Necrosulfonamide from Tocris? If so please let us know.

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Keywords: Necrosulfonamide, supplier, non-apoptotic, cell, death, necroptosis, necrosis, necrosome, mixed, lineage, kinase, domain-like, protein, MLKL, receptor, interacting, serine, threonine, kinases, 3, RIP3, Tocris Bioscience, Other Apoptosis products

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Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

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Apoptosis Pathway

Apoptosis Signaling Pathway

Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.

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