Cat. No. 5025
Chemical Name: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)
Biological ActivityNecroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kreuzaler et al (2012) Killing a cancer: what are the alternatives? Nat.Rev.Cancer. 12 411. PMID: 22576162.
Sun et al (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148 213. PMID: 22265413.
Zhou et al (2012) New components of the necroptotic pathway. Protein Cell 3 811. PMID: 23073834.
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Citations are publications that use Tocris products. Selected citations for Necrosulfonamide include:
Bittner et al (2016) Death receptor 3 mediates necroptotic cell death Cellular and Molecular Life Sciences. PMID: 27592300.
Gonzalez-Juarbe et al (2015) Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. Channels (Austin) 11 e1005337. PMID: 26659062.
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Keywords: Necrosulfonamide, supplier, non-apoptotic, cell, death, necroptosis, necrosis, necrosome, mixed, lineage, kinase, domain-like, protein, MLKL, receptor, interacting, serine, threonine, kinases, 3, RIP3, Tocris Bioscience, Other Apoptosis products