Cat. No. 4931
Chemical Name: N2-[[3-[(2,1,3-Benzothiadiazol-4-yl
Biological ActivityNeuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Increases chemo-sensitivity of A549 cells in combination with Taxol (Cat. No. 1097). Blocks pro-tumorigenic M2 polarization in glioma-associated microglia and macrophages and reduces tumor growth and vascularization in NSG mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Grun et al (2016) VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene. 35 4379. PMID: 26804163.
Miyauchi et al (2016) Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression. Oncotarget. 7 9801. PMID: 26755653.
Jarvis et al (2010) Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J.Med.Chem. 53 2215. PMID: 20151671.
If you know of a relevant reference for EG 00229 please let us know.
Citations are publications that use Tocris products. Selected citations for EG 00229 include:
Nissen et al (2013) Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J.Neurochem. 127 394. PMID: 24033337.
Do you know of a great paper that uses EG 00229 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: EG 00229, supplier, EG00229, antagonists, VEGFA, receptors, neuropilin, nrp1, taxol, increases, chemo, sensitivity, Vascular, endothelial, growth, factor, Tocris Bioscience, VEGFR products
Find multiple products by catalog number
New Products in this Area
Potent and selective PDGFR inhibitorGSK 1363089
Potent inhibitor of MET, VEGFR2, Ron and AXLPF 06273340
Potent and selective pan-Trk inhibitor; peripherally restricted
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for Neuroscience 2017.