EG 00229

Cat. No. 4931

EG 00229 C17H19N7O5S3 [1018927-63-3]

Price and Availability

For EG 00229 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine

Biological Activity

Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Increases chemo-sensitivity of A549 cells in combination with Taxol (Cat. No. 1097).

Technical Data

M.Wt:
497.57
Formula:
C17H19N7O5S3
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1018927-63-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Jarvis et al (2010) Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J.Med.Chem. 53 2215. PMID: 20151671.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses EG 00229 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: EG 00229, supplier, EG00229, antagonists, VEGFA, receptors, neuropilin, nrp1, taxol, increases, chemo, sensitivity, Vascular, endothelial, growth, factor, Tocris Bioscience, VEGFR products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

divider line

VEGF Pathway

VEGF Signaling Pathway

VEGF signaling regulates vascular development (vasculogenesis) and the formation of new blood vessels (angiogenesis). View pathway or download PDF today.

divider line

New Products in this Area

HIOC

Selective TrkB receptor agonist; neuroprotectant

AV 412

Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases

CP 724714

Potent and selective ErbB2 inhibitor

Mitoglitazone

Insulin sensitizer; exhibits low binding affinity at PPARγ

PF 6274484

High affinity and potent covalent EGFR kinase inhibitor

Canertinib dihydrochloride

Potent EGFR kinase inhibitor

CHMFL-FLT3-122

Potent and selective FLT3 inhibitor

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.