Cat. No. 4905
Chemical Name: N-[(1,2-Dihydro-1,6-dimethyl-2-oxo-
Biological ActivityNegative control of UNC 1999 (Cat. No. 4904). Exhibits 1000-fold lower potency than active analog (IC50 values are 62 and >200 μM for EZH1 and EZH2, respectively).
Licensing InformationThis compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary on the SGC website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Xu et al (2015) Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood 125 346. PMID: 25395428.
Konze et al (2013) An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS Chem.Biol. 8 1324. PMID: 23614352.
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Keywords: UNC 2400, supplier, UNC2400, Negative, controls, UNC1999, EZH1, EZH2, histone, methyltransferase, Tocris Bioscience, Lysine Methyltransferase Inhibitor products
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Tocris has a collaboration with the Structural Genomics Consortium (SGC) to provide the latest high quality epigenetics probes.