UNC 2400

Cat. No. 4905

UNC 2400 C35H47N7O2 [1433200-49-7]

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Chemical Name: N-[(1,2-Dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]-N-methyl-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide

Biological Activity

Negative control of UNC 1999 (Cat. No. 4904). Exhibits 1000-fold lower potency than active analog (IC50 values are 62 and >200 μM for EZH1 and EZH2, respectively).

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary on the SGC website.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Xu et al (2015) Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood 125 346. PMID: 25395428.

Konze et al (2013) An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS Chem.Biol. 8 1324. PMID: 23614352.

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Keywords: UNC 2400, supplier, UNC2400, Negative, controls, UNC1999, EZH1, EZH2, histone, methyltransferase, Tocris Bioscience, Lysine Methyltransferase Inhibitor products

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